Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

Elevated intraocular pressure (IOP) is a heritable risk factor for primary open angle glaucoma. Using forward mouse genetics, cell biology, pharmacology and human genetic data, the authors identify CACNA2D1 as an IOP risk gene that can be therapeutically targeted by the drug pregabalin in animal mod...

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Autores principales:	Sumana R. Chintalapudi, Doaa Maria, Xiang Di Wang, Jessica N. Cooke Bailey, NEIGHBORHOOD consortium, International Glaucoma Genetics consortium, Pirro G. Hysi, Janey L. Wiggs, Robert W. Williams, Monica M. Jablonski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af4437df6004461cb8840a6beeadf9f9
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spelling	oai:doaj.org-article:af4437df6004461cb8840a6beeadf9f92021-12-02T14:42:22ZSystems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility10.1038/s41467-017-00837-52041-1723https://doaj.org/article/af4437df6004461cb8840a6beeadf9f92017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00837-5https://doaj.org/toc/2041-1723Elevated intraocular pressure (IOP) is a heritable risk factor for primary open angle glaucoma. Using forward mouse genetics, cell biology, pharmacology and human genetic data, the authors identify CACNA2D1 as an IOP risk gene that can be therapeutically targeted by the drug pregabalin in animal models.Sumana R. ChintalapudiDoaa MariaXiang Di WangJessica N. Cooke BaileyNEIGHBORHOOD consortiumInternational Glaucoma Genetics consortiumPirro G. HysiJaney L. WiggsRobert W. WilliamsMonica M. JablonskiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sumana R. Chintalapudi Doaa Maria Xiang Di Wang Jessica N. Cooke Bailey NEIGHBORHOOD consortium International Glaucoma Genetics consortium Pirro G. Hysi Janey L. Wiggs Robert W. Williams Monica M. Jablonski Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
description	Elevated intraocular pressure (IOP) is a heritable risk factor for primary open angle glaucoma. Using forward mouse genetics, cell biology, pharmacology and human genetic data, the authors identify CACNA2D1 as an IOP risk gene that can be therapeutically targeted by the drug pregabalin in animal models.
format	article
author	Sumana R. Chintalapudi Doaa Maria Xiang Di Wang Jessica N. Cooke Bailey NEIGHBORHOOD consortium International Glaucoma Genetics consortium Pirro G. Hysi Janey L. Wiggs Robert W. Williams Monica M. Jablonski
author_facet	Sumana R. Chintalapudi Doaa Maria Xiang Di Wang Jessica N. Cooke Bailey NEIGHBORHOOD consortium International Glaucoma Genetics consortium Pirro G. Hysi Janey L. Wiggs Robert W. Williams Monica M. Jablonski
author_sort	Sumana R. Chintalapudi
title	Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
title_short	Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
title_full	Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
title_fullStr	Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
title_full_unstemmed	Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
title_sort	systems genetics identifies a role for cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/af4437df6004461cb8840a6beeadf9f9
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Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

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