Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice

The mechanisms that mediate the effects of weight loss surgeries such as vertical sleeve gastrectomy (VSG) are incompletely understood. Here the authors show that intestinal FGF15 is necessary to improve glucose tolerance and to prevent the loss of muscle and bone mass after VSG, potentially via pro...

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Autores principales:	Nadejda Bozadjieva-Kramer, Jae Hoon Shin, Yikai Shao, Ruth Gutierrez-Aguilar, Ziru Li, Kristy M. Heppner, Samuel Chiang, Sara G. Vargo, Katrina Granger, Darleen A. Sandoval, Ormond A. MacDougald, Randy J. Seeley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af44be2074044e2db785c4c8cb983aeb
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spelling	oai:doaj.org-article:af44be2074044e2db785c4c8cb983aeb2021-12-02T16:35:46ZIntestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice10.1038/s41467-021-24914-y2041-1723https://doaj.org/article/af44be2074044e2db785c4c8cb983aeb2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24914-yhttps://doaj.org/toc/2041-1723The mechanisms that mediate the effects of weight loss surgeries such as vertical sleeve gastrectomy (VSG) are incompletely understood. Here the authors show that intestinal FGF15 is necessary to improve glucose tolerance and to prevent the loss of muscle and bone mass after VSG, potentially via protection against bile acid toxicity.Nadejda Bozadjieva-KramerJae Hoon ShinYikai ShaoRuth Gutierrez-AguilarZiru LiKristy M. HeppnerSamuel ChiangSara G. VargoKatrina GrangerDarleen A. SandovalOrmond A. MacDougaldRandy J. SeeleyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nadejda Bozadjieva-Kramer Jae Hoon Shin Yikai Shao Ruth Gutierrez-Aguilar Ziru Li Kristy M. Heppner Samuel Chiang Sara G. Vargo Katrina Granger Darleen A. Sandoval Ormond A. MacDougald Randy J. Seeley Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
description	The mechanisms that mediate the effects of weight loss surgeries such as vertical sleeve gastrectomy (VSG) are incompletely understood. Here the authors show that intestinal FGF15 is necessary to improve glucose tolerance and to prevent the loss of muscle and bone mass after VSG, potentially via protection against bile acid toxicity.
format	article
author	Nadejda Bozadjieva-Kramer Jae Hoon Shin Yikai Shao Ruth Gutierrez-Aguilar Ziru Li Kristy M. Heppner Samuel Chiang Sara G. Vargo Katrina Granger Darleen A. Sandoval Ormond A. MacDougald Randy J. Seeley
author_facet	Nadejda Bozadjieva-Kramer Jae Hoon Shin Yikai Shao Ruth Gutierrez-Aguilar Ziru Li Kristy M. Heppner Samuel Chiang Sara G. Vargo Katrina Granger Darleen A. Sandoval Ormond A. MacDougald Randy J. Seeley
author_sort	Nadejda Bozadjieva-Kramer
title	Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
title_short	Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
title_full	Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
title_fullStr	Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
title_full_unstemmed	Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice
title_sort	intestinal-derived fgf15 protects against deleterious effects of vertical sleeve gastrectomy in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/af44be2074044e2db785c4c8cb983aeb
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Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice

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