Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease

Delta-secretases are associated with Alzheimer’s disease (AD) as they cleave both amyloid precursor protein and tau. Here the authors develop a series of orally bioactive small molecule delta-secretase inhibitors and report its therapeutic effects in mouse models of AD.

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhentao Zhang, Obiamaka Obianyo, Elfriede Dall, Yuhong Du, Haian Fu, Xia Liu, Seong Su Kang, Mingke Song, Shan-Ping Yu, Chiara Cabrele, Mario Schubert, Xiaoguang Li, Jian-Zhi Wang, Hans Brandstetter, Keqiang Ye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af4749718ac94cb988dc9847eb692495
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:af4749718ac94cb988dc9847eb692495
record_format	dspace
spelling	oai:doaj.org-article:af4749718ac94cb988dc9847eb6924952021-12-02T14:42:23ZInhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease10.1038/ncomms147402041-1723https://doaj.org/article/af4749718ac94cb988dc9847eb6924952017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14740https://doaj.org/toc/2041-1723Delta-secretases are associated with Alzheimer’s disease (AD) as they cleave both amyloid precursor protein and tau. Here the authors develop a series of orally bioactive small molecule delta-secretase inhibitors and report its therapeutic effects in mouse models of AD.Zhentao ZhangObiamaka ObianyoElfriede DallYuhong DuHaian FuXia LiuSeong Su KangMingke SongShan-Ping YuChiara CabreleMario SchubertXiaoguang LiJian-Zhi WangHans BrandstetterKeqiang YeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhentao Zhang Obiamaka Obianyo Elfriede Dall Yuhong Du Haian Fu Xia Liu Seong Su Kang Mingke Song Shan-Ping Yu Chiara Cabrele Mario Schubert Xiaoguang Li Jian-Zhi Wang Hans Brandstetter Keqiang Ye Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease
description	Delta-secretases are associated with Alzheimer’s disease (AD) as they cleave both amyloid precursor protein and tau. Here the authors develop a series of orally bioactive small molecule delta-secretase inhibitors and report its therapeutic effects in mouse models of AD.
format	article
author	Zhentao Zhang Obiamaka Obianyo Elfriede Dall Yuhong Du Haian Fu Xia Liu Seong Su Kang Mingke Song Shan-Ping Yu Chiara Cabrele Mario Schubert Xiaoguang Li Jian-Zhi Wang Hans Brandstetter Keqiang Ye
author_facet	Zhentao Zhang Obiamaka Obianyo Elfriede Dall Yuhong Du Haian Fu Xia Liu Seong Su Kang Mingke Song Shan-Ping Yu Chiara Cabrele Mario Schubert Xiaoguang Li Jian-Zhi Wang Hans Brandstetter Keqiang Ye
author_sort	Zhentao Zhang
title	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease
title_short	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease
title_full	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease
title_fullStr	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease
title_full_unstemmed	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease
title_sort	inhibition of delta-secretase improves cognitive functions in mouse models of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/af4749718ac94cb988dc9847eb692495
work_keys_str_mv	AT zhentaozhang inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT obiamakaobianyo inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT elfriededall inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT yuhongdu inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT haianfu inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT xialiu inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT seongsukang inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT mingkesong inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT shanpingyu inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT chiaracabrele inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT marioschubert inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT xiaoguangli inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT jianzhiwang inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT hansbrandstetter inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease AT keqiangye inhibitionofdeltasecretaseimprovescognitivefunctionsinmousemodelsofalzheimersdisease
_version_	1718389710184775680

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease

Ejemplares similares