LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression

Liver tumour-initiating cells (TICs) may be responsible for liver cancer initiation and recurrence. In this article, the authors show that a previously unidentified lncRNA, LncSox4, is highly expressed in liver cancer TICs and regulates TIC self-renewal through the Stat3/SOX4 axis.

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Autores principales:	Zhen-zhen Chen, Lan Huang, Ya-hong Wu, Wen-jie Zhai, Ping-ping Zhu, Yan-feng Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af4da882b3d24660a0f557ced5498b6f
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spelling	oai:doaj.org-article:af4da882b3d24660a0f557ced5498b6f2021-12-02T14:39:12ZLncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression10.1038/ncomms125982041-1723https://doaj.org/article/af4da882b3d24660a0f557ced5498b6f2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12598https://doaj.org/toc/2041-1723Liver tumour-initiating cells (TICs) may be responsible for liver cancer initiation and recurrence. In this article, the authors show that a previously unidentified lncRNA, LncSox4, is highly expressed in liver cancer TICs and regulates TIC self-renewal through the Stat3/SOX4 axis.Zhen-zhen ChenLan HuangYa-hong WuWen-jie ZhaiPing-ping ZhuYan-feng GaoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhen-zhen Chen Lan Huang Ya-hong Wu Wen-jie Zhai Ping-ping Zhu Yan-feng Gao LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression
description	Liver tumour-initiating cells (TICs) may be responsible for liver cancer initiation and recurrence. In this article, the authors show that a previously unidentified lncRNA, LncSox4, is highly expressed in liver cancer TICs and regulates TIC self-renewal through the Stat3/SOX4 axis.
format	article
author	Zhen-zhen Chen Lan Huang Ya-hong Wu Wen-jie Zhai Ping-ping Zhu Yan-feng Gao
author_facet	Zhen-zhen Chen Lan Huang Ya-hong Wu Wen-jie Zhai Ping-ping Zhu Yan-feng Gao
author_sort	Zhen-zhen Chen
title	LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression
title_short	LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression
title_full	LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression
title_fullStr	LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression
title_full_unstemmed	LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression
title_sort	lncsox4 promotes the self-renewal of liver tumour-initiating cells through stat3-mediated sox4 expression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/af4da882b3d24660a0f557ced5498b6f
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LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression

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