LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression

Liver tumour-initiating cells (TICs) may be responsible for liver cancer initiation and recurrence. In this article, the authors show that a previously unidentified lncRNA, LncSox4, is highly expressed in liver cancer TICs and regulates TIC self-renewal through the Stat3/SOX4 axis.

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Autores principales: Zhen-zhen Chen, Lan Huang, Ya-hong Wu, Wen-jie Zhai, Ping-ping Zhu, Yan-feng Gao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/af4da882b3d24660a0f557ced5498b6f
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