RET rearrangements are actionable alterations in breast cancer

Fusions of the gene RET have been described in thyroid and lung cancers. Here, the AUs identify RET gene alterations, including known fusions, novel fusions, and rearrangements in breast cancer (BC) that are involved in the tumorigenic process and show the benefit of RET therapy in a recurrent BC pa...

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Autores principales:	Bhavna S. Paratala, Jon H. Chung, Casey B. Williams, Bahar Yilmazel, Whitney Petrosky, Kirstin Williams, Alexa B. Schrock, Laurie M. Gay, Ellen Lee, Sonia C. Dolfi, Kien Pham, Stephanie Lin, Ming Yao, Atul Kulkarni, Frances DiClemente, Chen Liu, Lorna Rodriguez-Rodriguez, Shridar Ganesan, Jeffrey S. Ross, Siraj M. Ali, Brian Leyland-Jones, Kim M. Hirshfield
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af4ef9c2d18542d6986221a4da000c4e
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spelling	oai:doaj.org-article:af4ef9c2d18542d6986221a4da000c4e2021-12-02T15:33:46ZRET rearrangements are actionable alterations in breast cancer10.1038/s41467-018-07341-42041-1723https://doaj.org/article/af4ef9c2d18542d6986221a4da000c4e2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07341-4https://doaj.org/toc/2041-1723Fusions of the gene RET have been described in thyroid and lung cancers. Here, the AUs identify RET gene alterations, including known fusions, novel fusions, and rearrangements in breast cancer (BC) that are involved in the tumorigenic process and show the benefit of RET therapy in a recurrent BC patient carrying the NCOA4-RET fusion.Bhavna S. ParatalaJon H. ChungCasey B. WilliamsBahar YilmazelWhitney PetroskyKirstin WilliamsAlexa B. SchrockLaurie M. GayEllen LeeSonia C. DolfiKien PhamStephanie LinMing YaoAtul KulkarniFrances DiClementeChen LiuLorna Rodriguez-RodriguezShridar GanesanJeffrey S. RossSiraj M. AliBrian Leyland-JonesKim M. HirshfieldNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bhavna S. Paratala Jon H. Chung Casey B. Williams Bahar Yilmazel Whitney Petrosky Kirstin Williams Alexa B. Schrock Laurie M. Gay Ellen Lee Sonia C. Dolfi Kien Pham Stephanie Lin Ming Yao Atul Kulkarni Frances DiClemente Chen Liu Lorna Rodriguez-Rodriguez Shridar Ganesan Jeffrey S. Ross Siraj M. Ali Brian Leyland-Jones Kim M. Hirshfield RET rearrangements are actionable alterations in breast cancer
description	Fusions of the gene RET have been described in thyroid and lung cancers. Here, the AUs identify RET gene alterations, including known fusions, novel fusions, and rearrangements in breast cancer (BC) that are involved in the tumorigenic process and show the benefit of RET therapy in a recurrent BC patient carrying the NCOA4-RET fusion.
format	article
author	Bhavna S. Paratala Jon H. Chung Casey B. Williams Bahar Yilmazel Whitney Petrosky Kirstin Williams Alexa B. Schrock Laurie M. Gay Ellen Lee Sonia C. Dolfi Kien Pham Stephanie Lin Ming Yao Atul Kulkarni Frances DiClemente Chen Liu Lorna Rodriguez-Rodriguez Shridar Ganesan Jeffrey S. Ross Siraj M. Ali Brian Leyland-Jones Kim M. Hirshfield
author_facet	Bhavna S. Paratala Jon H. Chung Casey B. Williams Bahar Yilmazel Whitney Petrosky Kirstin Williams Alexa B. Schrock Laurie M. Gay Ellen Lee Sonia C. Dolfi Kien Pham Stephanie Lin Ming Yao Atul Kulkarni Frances DiClemente Chen Liu Lorna Rodriguez-Rodriguez Shridar Ganesan Jeffrey S. Ross Siraj M. Ali Brian Leyland-Jones Kim M. Hirshfield
author_sort	Bhavna S. Paratala
title	RET rearrangements are actionable alterations in breast cancer
title_short	RET rearrangements are actionable alterations in breast cancer
title_full	RET rearrangements are actionable alterations in breast cancer
title_fullStr	RET rearrangements are actionable alterations in breast cancer
title_full_unstemmed	RET rearrangements are actionable alterations in breast cancer
title_sort	ret rearrangements are actionable alterations in breast cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/af4ef9c2d18542d6986221a4da000c4e
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RET rearrangements are actionable alterations in breast cancer

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