Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia
The regulation of resistance to IDH inhibitors in acute myeloid leukaemia is not completely understood. Here the authors reveal with integrative multi-omics analyses that stemness features are major drivers of primary resistance, while high-risk mutations drive acquired resistance.
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Nature Portfolio
2021
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oai:doaj.org-article:af530f137f2d430f8c1dd47dd38789db2021-12-02T14:35:46ZLeukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia10.1038/s41467-021-22874-x2041-1723https://doaj.org/article/af530f137f2d430f8c1dd47dd38789db2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22874-xhttps://doaj.org/toc/2041-1723The regulation of resistance to IDH inhibitors in acute myeloid leukaemia is not completely understood. Here the authors reveal with integrative multi-omics analyses that stemness features are major drivers of primary resistance, while high-risk mutations drive acquired resistance.Feng WangKiyomi MoritaCourtney D. DiNardoKen FurudateTomoyuki TanakaYuanqing YanKeyur P. PatelKyle J. MacBethBin WuGuowen LiuMark FrattiniJairo A. MatthewsLatasha D. LittleCurtis GumbsXingzhi SongJianhua ZhangErika J. ThompsonTapan M. KadiaGuillermo Garcia-ManeroElias JabbourFarhad RavandiKapil N. BhallaMarina KonoplevaHagop M. KantarjianP. Andrew FutrealKoichi TakahashiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Feng Wang Kiyomi Morita Courtney D. DiNardo Ken Furudate Tomoyuki Tanaka Yuanqing Yan Keyur P. Patel Kyle J. MacBeth Bin Wu Guowen Liu Mark Frattini Jairo A. Matthews Latasha D. Little Curtis Gumbs Xingzhi Song Jianhua Zhang Erika J. Thompson Tapan M. Kadia Guillermo Garcia-Manero Elias Jabbour Farhad Ravandi Kapil N. Bhalla Marina Konopleva Hagop M. Kantarjian P. Andrew Futreal Koichi Takahashi Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia |
| description |
The regulation of resistance to IDH inhibitors in acute myeloid leukaemia is not completely understood. Here the authors reveal with integrative multi-omics analyses that stemness features are major drivers of primary resistance, while high-risk mutations drive acquired resistance. |
| format |
article |
| author |
Feng Wang Kiyomi Morita Courtney D. DiNardo Ken Furudate Tomoyuki Tanaka Yuanqing Yan Keyur P. Patel Kyle J. MacBeth Bin Wu Guowen Liu Mark Frattini Jairo A. Matthews Latasha D. Little Curtis Gumbs Xingzhi Song Jianhua Zhang Erika J. Thompson Tapan M. Kadia Guillermo Garcia-Manero Elias Jabbour Farhad Ravandi Kapil N. Bhalla Marina Konopleva Hagop M. Kantarjian P. Andrew Futreal Koichi Takahashi |
| author_facet |
Feng Wang Kiyomi Morita Courtney D. DiNardo Ken Furudate Tomoyuki Tanaka Yuanqing Yan Keyur P. Patel Kyle J. MacBeth Bin Wu Guowen Liu Mark Frattini Jairo A. Matthews Latasha D. Little Curtis Gumbs Xingzhi Song Jianhua Zhang Erika J. Thompson Tapan M. Kadia Guillermo Garcia-Manero Elias Jabbour Farhad Ravandi Kapil N. Bhalla Marina Konopleva Hagop M. Kantarjian P. Andrew Futreal Koichi Takahashi |
| author_sort |
Feng Wang |
| title |
Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia |
| title_short |
Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia |
| title_full |
Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia |
| title_fullStr |
Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia |
| title_full_unstemmed |
Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia |
| title_sort |
leukemia stemness and co-occurring mutations drive resistance to idh inhibitors in acute myeloid leukemia |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/af530f137f2d430f8c1dd47dd38789db |
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