Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.

<h4>Objective</h4>The aim of this study was to determine (i) the effect of maternal obesity and gestational diabetes mellitus (GDM) on (i) the circulating levels of omentin-1 in cord and maternal plasma, and (ii) gene expression and release of omentin-1 from human placenta and adipose ti...

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Autores principales:	Gillian Barker, Ratana Lim, Harry M Georgiou, Martha Lappas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/af577952d53c406aba7b0dba2dd1b087
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spelling	oai:doaj.org-article:af577952d53c406aba7b0dba2dd1b0872021-11-18T07:07:22ZOmentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.1932-620310.1371/journal.pone.0042943https://doaj.org/article/af577952d53c406aba7b0dba2dd1b0872012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22952622/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>The aim of this study was to determine (i) the effect of maternal obesity and gestational diabetes mellitus (GDM) on (i) the circulating levels of omentin-1 in cord and maternal plasma, and (ii) gene expression and release of omentin-1 from human placenta and adipose tissue. The effect of pregnancy on circulating omentin-1 levels was also determined.<h4>Design</h4>Omentin-1 levels were measured in maternal and cord plasma from obese and non-obese normal glucose tolerant women (NGT; n = 44) and women with GDM (n = 39) at the time of term elective Caesarean section. Placenta and adipose tissue expression and release of omentin-1 was measured from 22 NGT and 22 GDM women collected at the time of term elective Caesarean section. Omentin-1 levels were also measured in maternal plasma from 13 NGT women at 11 and 28 weeks gestation and 7 weeks postpartum.<h4>Results</h4>Maternal obesity was associated with significantly lower omentin-1 levels in maternal plasma; however, there was no effect of maternal obesity on cord omentin levels. Omentin-1 gene expression was lower in placenta and adipose tissue obtained from women with pre-existing obesity. In addition to this, adipose tissue release of omentin-1 was significantly lower from obese pregnant women. Omentin-1 levels were significantly lower in non-obese GDM compared to non-obese NGT women. However, there was no difference in omentin-1 levels between obese NGT and obese GDM women. There was no effect of GDM on cord omentin levels, and placental and adipose tissue omentin-1 expression. Maternal omentin-1 levels were negatively correlated with fetal birthweight and fetal ponderal index.<h4>Conclusions</h4>The data presented in this study demonstrate that pre-existing maternal obesity is associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. Alteration in omentin-1 in pregnancy may influence the development of metabolic disorders in offspring later in life.Gillian BarkerRatana LimHarry M GeorgiouMartha LappasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42943 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gillian Barker Ratana Lim Harry M Georgiou Martha Lappas Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
description	<h4>Objective</h4>The aim of this study was to determine (i) the effect of maternal obesity and gestational diabetes mellitus (GDM) on (i) the circulating levels of omentin-1 in cord and maternal plasma, and (ii) gene expression and release of omentin-1 from human placenta and adipose tissue. The effect of pregnancy on circulating omentin-1 levels was also determined.<h4>Design</h4>Omentin-1 levels were measured in maternal and cord plasma from obese and non-obese normal glucose tolerant women (NGT; n = 44) and women with GDM (n = 39) at the time of term elective Caesarean section. Placenta and adipose tissue expression and release of omentin-1 was measured from 22 NGT and 22 GDM women collected at the time of term elective Caesarean section. Omentin-1 levels were also measured in maternal plasma from 13 NGT women at 11 and 28 weeks gestation and 7 weeks postpartum.<h4>Results</h4>Maternal obesity was associated with significantly lower omentin-1 levels in maternal plasma; however, there was no effect of maternal obesity on cord omentin levels. Omentin-1 gene expression was lower in placenta and adipose tissue obtained from women with pre-existing obesity. In addition to this, adipose tissue release of omentin-1 was significantly lower from obese pregnant women. Omentin-1 levels were significantly lower in non-obese GDM compared to non-obese NGT women. However, there was no difference in omentin-1 levels between obese NGT and obese GDM women. There was no effect of GDM on cord omentin levels, and placental and adipose tissue omentin-1 expression. Maternal omentin-1 levels were negatively correlated with fetal birthweight and fetal ponderal index.<h4>Conclusions</h4>The data presented in this study demonstrate that pre-existing maternal obesity is associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. Alteration in omentin-1 in pregnancy may influence the development of metabolic disorders in offspring later in life.
format	article
author	Gillian Barker Ratana Lim Harry M Georgiou Martha Lappas
author_facet	Gillian Barker Ratana Lim Harry M Georgiou Martha Lappas
author_sort	Gillian Barker
title	Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
title_short	Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
title_full	Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
title_fullStr	Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
title_full_unstemmed	Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
title_sort	omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/af577952d53c406aba7b0dba2dd1b087
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Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.

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