Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.

<h4>Objective</h4>The aim of this study was to determine (i) the effect of maternal obesity and gestational diabetes mellitus (GDM) on (i) the circulating levels of omentin-1 in cord and maternal plasma, and (ii) gene expression and release of omentin-1 from human placenta and adipose ti...

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Autores principales: Gillian Barker, Ratana Lim, Harry M Georgiou, Martha Lappas
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Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/af577952d53c406aba7b0dba2dd1b087
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spelling oai:doaj.org-article:af577952d53c406aba7b0dba2dd1b0872021-11-18T07:07:22ZOmentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.1932-620310.1371/journal.pone.0042943https://doaj.org/article/af577952d53c406aba7b0dba2dd1b0872012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22952622/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>The aim of this study was to determine (i) the effect of maternal obesity and gestational diabetes mellitus (GDM) on (i) the circulating levels of omentin-1 in cord and maternal plasma, and (ii) gene expression and release of omentin-1 from human placenta and adipose tissue. The effect of pregnancy on circulating omentin-1 levels was also determined.<h4>Design</h4>Omentin-1 levels were measured in maternal and cord plasma from obese and non-obese normal glucose tolerant women (NGT; n = 44) and women with GDM (n = 39) at the time of term elective Caesarean section. Placenta and adipose tissue expression and release of omentin-1 was measured from 22 NGT and 22 GDM women collected at the time of term elective Caesarean section. Omentin-1 levels were also measured in maternal plasma from 13 NGT women at 11 and 28 weeks gestation and 7 weeks postpartum.<h4>Results</h4>Maternal obesity was associated with significantly lower omentin-1 levels in maternal plasma; however, there was no effect of maternal obesity on cord omentin levels. Omentin-1 gene expression was lower in placenta and adipose tissue obtained from women with pre-existing obesity. In addition to this, adipose tissue release of omentin-1 was significantly lower from obese pregnant women. Omentin-1 levels were significantly lower in non-obese GDM compared to non-obese NGT women. However, there was no difference in omentin-1 levels between obese NGT and obese GDM women. There was no effect of GDM on cord omentin levels, and placental and adipose tissue omentin-1 expression. Maternal omentin-1 levels were negatively correlated with fetal birthweight and fetal ponderal index.<h4>Conclusions</h4>The data presented in this study demonstrate that pre-existing maternal obesity is associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. Alteration in omentin-1 in pregnancy may influence the development of metabolic disorders in offspring later in life.Gillian BarkerRatana LimHarry M GeorgiouMartha LappasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e42943 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Gillian Barker
Ratana Lim
Harry M Georgiou
Martha Lappas
Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
description <h4>Objective</h4>The aim of this study was to determine (i) the effect of maternal obesity and gestational diabetes mellitus (GDM) on (i) the circulating levels of omentin-1 in cord and maternal plasma, and (ii) gene expression and release of omentin-1 from human placenta and adipose tissue. The effect of pregnancy on circulating omentin-1 levels was also determined.<h4>Design</h4>Omentin-1 levels were measured in maternal and cord plasma from obese and non-obese normal glucose tolerant women (NGT; n = 44) and women with GDM (n = 39) at the time of term elective Caesarean section. Placenta and adipose tissue expression and release of omentin-1 was measured from 22 NGT and 22 GDM women collected at the time of term elective Caesarean section. Omentin-1 levels were also measured in maternal plasma from 13 NGT women at 11 and 28 weeks gestation and 7 weeks postpartum.<h4>Results</h4>Maternal obesity was associated with significantly lower omentin-1 levels in maternal plasma; however, there was no effect of maternal obesity on cord omentin levels. Omentin-1 gene expression was lower in placenta and adipose tissue obtained from women with pre-existing obesity. In addition to this, adipose tissue release of omentin-1 was significantly lower from obese pregnant women. Omentin-1 levels were significantly lower in non-obese GDM compared to non-obese NGT women. However, there was no difference in omentin-1 levels between obese NGT and obese GDM women. There was no effect of GDM on cord omentin levels, and placental and adipose tissue omentin-1 expression. Maternal omentin-1 levels were negatively correlated with fetal birthweight and fetal ponderal index.<h4>Conclusions</h4>The data presented in this study demonstrate that pre-existing maternal obesity is associated with lower omentin-1 expression in placenta, adipose tissue and maternal plasma. Alteration in omentin-1 in pregnancy may influence the development of metabolic disorders in offspring later in life.
format article
author Gillian Barker
Ratana Lim
Harry M Georgiou
Martha Lappas
author_facet Gillian Barker
Ratana Lim
Harry M Georgiou
Martha Lappas
author_sort Gillian Barker
title Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
title_short Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
title_full Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
title_fullStr Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
title_full_unstemmed Omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
title_sort omentin-1 is decreased in maternal plasma, placenta and adipose tissue of women with pre-existing obesity.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/af577952d53c406aba7b0dba2dd1b087
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AT harrymgeorgiou omentin1isdecreasedinmaternalplasmaplacentaandadiposetissueofwomenwithpreexistingobesity
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