Gut non-bacterial microbiota contributing to alcohol-associated liver disease

Intestinal microbiota, dominated by bacteria, plays an important role in the occurrence and the development of alcohol-associated liver disease (ALD), which is one of the most common liver diseases around the world. With sufficient studies focusing on the gut bacterial community, chronic alcohol con...

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Autores principales:	Wenkang Gao, Yixin Zhu, Jin Ye, Huikuan Chu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	alcohol-associated liver disease gut-liver axis gut barrier liver sinusoid endothelial cells mycobiome clec7a virome archaeome immune response Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/af59e97e962345bd97eef5d7f8648a82
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spelling	oai:doaj.org-article:af59e97e962345bd97eef5d7f8648a822021-11-04T15:00:42ZGut non-bacterial microbiota contributing to alcohol-associated liver disease1949-09761949-098410.1080/19490976.2021.1984122https://doaj.org/article/af59e97e962345bd97eef5d7f8648a822021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19490976.2021.1984122https://doaj.org/toc/1949-0976https://doaj.org/toc/1949-0984Intestinal microbiota, dominated by bacteria, plays an important role in the occurrence and the development of alcohol-associated liver disease (ALD), which is one of the most common liver diseases around the world. With sufficient studies focusing on the gut bacterial community, chronic alcohol consumption is now known as a key factor that alters the composition of gut bacterial community, increases intestinal permeability, causes intestinal dysfunction, induces bacterial translocation, and exacerbates the process of ALD via gut-liver axis. However, gut non-bacterial communities including fungi, viruses, and archaea, which may also participate in the disease, has received little attention relative to the gut bacterial community. This paper will systematically collect the latest literatures reporting non-bacterial communities in mammalian health and disease, and review their mechanisms in promoting the development of ALD including CLEC7A pathway, Candidalysin (a peptide toxin secreted by Candida albicans), metabolites, and other chemical substances secreted or regulated by gut commensal mycobiome, virome, and archaeome, hoping to bring novel insights on our current knowledge of ALD.Wenkang GaoYixin ZhuJin YeHuikuan ChuTaylor & Francis Grouparticlealcohol-associated liver diseasegut-liver axisgut barrierliver sinusoid endothelial cellsmycobiomeclec7aviromearchaeomeimmune responseDiseases of the digestive system. GastroenterologyRC799-869ENGut Microbes, Vol 13, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alcohol-associated liver disease gut-liver axis gut barrier liver sinusoid endothelial cells mycobiome clec7a virome archaeome immune response Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	alcohol-associated liver disease gut-liver axis gut barrier liver sinusoid endothelial cells mycobiome clec7a virome archaeome immune response Diseases of the digestive system. Gastroenterology RC799-869 Wenkang Gao Yixin Zhu Jin Ye Huikuan Chu Gut non-bacterial microbiota contributing to alcohol-associated liver disease
description	Intestinal microbiota, dominated by bacteria, plays an important role in the occurrence and the development of alcohol-associated liver disease (ALD), which is one of the most common liver diseases around the world. With sufficient studies focusing on the gut bacterial community, chronic alcohol consumption is now known as a key factor that alters the composition of gut bacterial community, increases intestinal permeability, causes intestinal dysfunction, induces bacterial translocation, and exacerbates the process of ALD via gut-liver axis. However, gut non-bacterial communities including fungi, viruses, and archaea, which may also participate in the disease, has received little attention relative to the gut bacterial community. This paper will systematically collect the latest literatures reporting non-bacterial communities in mammalian health and disease, and review their mechanisms in promoting the development of ALD including CLEC7A pathway, Candidalysin (a peptide toxin secreted by Candida albicans), metabolites, and other chemical substances secreted or regulated by gut commensal mycobiome, virome, and archaeome, hoping to bring novel insights on our current knowledge of ALD.
format	article
author	Wenkang Gao Yixin Zhu Jin Ye Huikuan Chu
author_facet	Wenkang Gao Yixin Zhu Jin Ye Huikuan Chu
author_sort	Wenkang Gao
title	Gut non-bacterial microbiota contributing to alcohol-associated liver disease
title_short	Gut non-bacterial microbiota contributing to alcohol-associated liver disease
title_full	Gut non-bacterial microbiota contributing to alcohol-associated liver disease
title_fullStr	Gut non-bacterial microbiota contributing to alcohol-associated liver disease
title_full_unstemmed	Gut non-bacterial microbiota contributing to alcohol-associated liver disease
title_sort	gut non-bacterial microbiota contributing to alcohol-associated liver disease
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/af59e97e962345bd97eef5d7f8648a82
work_keys_str_mv	AT wenkanggao gutnonbacterialmicrobiotacontributingtoalcoholassociatedliverdisease AT yixinzhu gutnonbacterialmicrobiotacontributingtoalcoholassociatedliverdisease AT jinye gutnonbacterialmicrobiotacontributingtoalcoholassociatedliverdisease AT huikuanchu gutnonbacterialmicrobiotacontributingtoalcoholassociatedliverdisease
_version_	1718444793191727104

Gut non-bacterial microbiota contributing to alcohol-associated liver disease

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