Neurodevelopment regulators miR-137 and miR-34 family as biomarkers for early and adult onset schizophrenia

Abstract Early-onset schizophrenia (EOS) may have stronger familial aggregation and a more severe outcome than adult-onset schizophrenia (AOS). MicroRNA (miRNA) takes on dual roles as a genetic and epigenetic modulator, which may mediate the influence of genetic risk. Neurological soft signs (NSS) a...

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Autores principales:	Bao-Yu Chen, Jin-Jia Lin, Ming-Kun Lu, Hung-Pin Tan, Fong-Lin Jang, Sheng-Hsiang Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/af5f35c8f9da41ce8df26dfab4c34c08
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spelling	oai:doaj.org-article:af5f35c8f9da41ce8df26dfab4c34c082021-12-02T16:15:05ZNeurodevelopment regulators miR-137 and miR-34 family as biomarkers for early and adult onset schizophrenia10.1038/s41537-021-00164-12334-265Xhttps://doaj.org/article/af5f35c8f9da41ce8df26dfab4c34c082021-07-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00164-1https://doaj.org/toc/2334-265XAbstract Early-onset schizophrenia (EOS) may have stronger familial aggregation and a more severe outcome than adult-onset schizophrenia (AOS). MicroRNA (miRNA) takes on dual roles as a genetic and epigenetic modulator, which may mediate the influence of genetic risk. Neurological soft signs (NSS) are neurological abnormalities that may be intermediate phenotypes or endophenotypes for schizophrenia. Our previous study found poorer performance on NSS tests from patients with EOS and their unaffected first-degree relatives. Thus, we aimed to identify a set of aberrant neurodevelopmental-related miRNAs that could serve as potential biomarkers for EOS or schizophrenia with NSS. This study included 215 schizophrenia patients (104 EOS and 111 AOS), 72 unaffected first-degree relatives, 31 patients with bipolar disorder, and 100 healthy controls. Differential expression analysis revealed that miR-137, miR-34b, and miR-34c were significantly up-regulated in patients with schizophrenia and their unaffected first-degree relatives compared to healthy controls. Receiver operating characteristic (ROC) analysis showed that the miR-137 expression signature could be used to discriminate between patients with EOS and healthy controls (AUC = 0.911). Additionally, miR-34b had the highest ability to discriminate between EOS and AOS (AUC = 0.810), which may indicate different aetiological pathways to disease onset. Moreover, miR-137 dysregulation was correlated with almost all NSS subscales (i.e., sensory integration, motor sequencing, etc.) and, when EOS patients with NSS, miR-137 expression discriminated these patients from healthy controls to a greater extent (AUC = 0.957). These findings support the potential for neurodevelopmental-related miRNAs to be used as indicators of vulnerability to EOS.Bao-Yu ChenJin-Jia LinMing-Kun LuHung-Pin TanFong-Lin JangSheng-Hsiang LinNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Bao-Yu Chen Jin-Jia Lin Ming-Kun Lu Hung-Pin Tan Fong-Lin Jang Sheng-Hsiang Lin Neurodevelopment regulators miR-137 and miR-34 family as biomarkers for early and adult onset schizophrenia
description	Abstract Early-onset schizophrenia (EOS) may have stronger familial aggregation and a more severe outcome than adult-onset schizophrenia (AOS). MicroRNA (miRNA) takes on dual roles as a genetic and epigenetic modulator, which may mediate the influence of genetic risk. Neurological soft signs (NSS) are neurological abnormalities that may be intermediate phenotypes or endophenotypes for schizophrenia. Our previous study found poorer performance on NSS tests from patients with EOS and their unaffected first-degree relatives. Thus, we aimed to identify a set of aberrant neurodevelopmental-related miRNAs that could serve as potential biomarkers for EOS or schizophrenia with NSS. This study included 215 schizophrenia patients (104 EOS and 111 AOS), 72 unaffected first-degree relatives, 31 patients with bipolar disorder, and 100 healthy controls. Differential expression analysis revealed that miR-137, miR-34b, and miR-34c were significantly up-regulated in patients with schizophrenia and their unaffected first-degree relatives compared to healthy controls. Receiver operating characteristic (ROC) analysis showed that the miR-137 expression signature could be used to discriminate between patients with EOS and healthy controls (AUC = 0.911). Additionally, miR-34b had the highest ability to discriminate between EOS and AOS (AUC = 0.810), which may indicate different aetiological pathways to disease onset. Moreover, miR-137 dysregulation was correlated with almost all NSS subscales (i.e., sensory integration, motor sequencing, etc.) and, when EOS patients with NSS, miR-137 expression discriminated these patients from healthy controls to a greater extent (AUC = 0.957). These findings support the potential for neurodevelopmental-related miRNAs to be used as indicators of vulnerability to EOS.
format	article
author	Bao-Yu Chen Jin-Jia Lin Ming-Kun Lu Hung-Pin Tan Fong-Lin Jang Sheng-Hsiang Lin
author_facet	Bao-Yu Chen Jin-Jia Lin Ming-Kun Lu Hung-Pin Tan Fong-Lin Jang Sheng-Hsiang Lin
author_sort	Bao-Yu Chen
title	Neurodevelopment regulators miR-137 and miR-34 family as biomarkers for early and adult onset schizophrenia
title_short	Neurodevelopment regulators miR-137 and miR-34 family as biomarkers for early and adult onset schizophrenia
title_full	Neurodevelopment regulators miR-137 and miR-34 family as biomarkers for early and adult onset schizophrenia
title_fullStr	Neurodevelopment regulators miR-137 and miR-34 family as biomarkers for early and adult onset schizophrenia
title_full_unstemmed	Neurodevelopment regulators miR-137 and miR-34 family as biomarkers for early and adult onset schizophrenia
title_sort	neurodevelopment regulators mir-137 and mir-34 family as biomarkers for early and adult onset schizophrenia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/af5f35c8f9da41ce8df26dfab4c34c08
work_keys_str_mv	AT baoyuchen neurodevelopmentregulatorsmir137andmir34familyasbiomarkersforearlyandadultonsetschizophrenia AT jinjialin neurodevelopmentregulatorsmir137andmir34familyasbiomarkersforearlyandadultonsetschizophrenia AT mingkunlu neurodevelopmentregulatorsmir137andmir34familyasbiomarkersforearlyandadultonsetschizophrenia AT hungpintan neurodevelopmentregulatorsmir137andmir34familyasbiomarkersforearlyandadultonsetschizophrenia AT fonglinjang neurodevelopmentregulatorsmir137andmir34familyasbiomarkersforearlyandadultonsetschizophrenia AT shenghsianglin neurodevelopmentregulatorsmir137andmir34familyasbiomarkersforearlyandadultonsetschizophrenia
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Neurodevelopment regulators miR-137 and miR-34 family as biomarkers for early and adult onset schizophrenia

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