Endogenous erythropoietin concentrations and association with retinopathy of prematurity and brain injury in preterm infants.

<h4>Background</h4>Endogenous erythropoietin (EPO) concentrations vary widely in preterm infants and may be associated with perinatal risk factors and neurological outcomes. Erythropoietin is elevated in fetal hypoxia but is also a potential neuroprotectant.<h4>Methods</h4>In...

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Autores principales:	Nancy M Fahim, Michael K Georgieff, Lei Zhang, Scott Naisbitt, Raghavendra B Rao, Terrie E Inder
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/af5f7d92152745279c7d790a10107abc
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spelling	oai:doaj.org-article:af5f7d92152745279c7d790a10107abc2021-12-02T20:11:07ZEndogenous erythropoietin concentrations and association with retinopathy of prematurity and brain injury in preterm infants.1932-620310.1371/journal.pone.0252655https://doaj.org/article/af5f7d92152745279c7d790a10107abc2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252655https://doaj.org/toc/1932-6203<h4>Background</h4>Endogenous erythropoietin (EPO) concentrations vary widely in preterm infants and may be associated with perinatal risk factors and neurological outcomes. Erythropoietin is elevated in fetal hypoxia but is also a potential neuroprotectant.<h4>Methods</h4>In a prospective study of 27 infants ≤ 30 weeks gestation, serum erythropoietin concentrations were measured during the first month of life, on day 1 and weeks 1, 2, and 4, and related to perinatal risk factors and outcomes including retinopathy of prematurity and cerebral injury evaluated near term-equivalent post menstrual age using magnetic resonance imaging with quantitative scoring.<h4>Results</h4>Lower birth weight was associated with higher EPO concentrations throughout the first 2 weeks of life (r = -0.6, p < 0.01). Higher day 1 and week 1 EPO concentrations were associated with lower Apgar score at 1 minute (r = - 0.5) and 5 minutes (r = -0.7), respectively (p < 0.01). Higher day 1 EPO concentrations and 2-week area under the curve were associated with increased risk (p = 0.01) and severity (r = 0.5, p < 0.02) of retinopathy of prematurity. Higher EPO concentrations at 2 weeks were associated with increased total brain injury score (r = 0.5, p < 0.05).<h4>Conclusion</h4>Elevated endogenous erythropoietin concentrations in the first two weeks of life are associated with lower birth weight and increased risk of adverse outcomes.Nancy M FahimMichael K GeorgieffLei ZhangScott NaisbittRaghavendra B RaoTerrie E InderPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252655 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nancy M Fahim Michael K Georgieff Lei Zhang Scott Naisbitt Raghavendra B Rao Terrie E Inder Endogenous erythropoietin concentrations and association with retinopathy of prematurity and brain injury in preterm infants.
description	<h4>Background</h4>Endogenous erythropoietin (EPO) concentrations vary widely in preterm infants and may be associated with perinatal risk factors and neurological outcomes. Erythropoietin is elevated in fetal hypoxia but is also a potential neuroprotectant.<h4>Methods</h4>In a prospective study of 27 infants ≤ 30 weeks gestation, serum erythropoietin concentrations were measured during the first month of life, on day 1 and weeks 1, 2, and 4, and related to perinatal risk factors and outcomes including retinopathy of prematurity and cerebral injury evaluated near term-equivalent post menstrual age using magnetic resonance imaging with quantitative scoring.<h4>Results</h4>Lower birth weight was associated with higher EPO concentrations throughout the first 2 weeks of life (r = -0.6, p < 0.01). Higher day 1 and week 1 EPO concentrations were associated with lower Apgar score at 1 minute (r = - 0.5) and 5 minutes (r = -0.7), respectively (p < 0.01). Higher day 1 EPO concentrations and 2-week area under the curve were associated with increased risk (p = 0.01) and severity (r = 0.5, p < 0.02) of retinopathy of prematurity. Higher EPO concentrations at 2 weeks were associated with increased total brain injury score (r = 0.5, p < 0.05).<h4>Conclusion</h4>Elevated endogenous erythropoietin concentrations in the first two weeks of life are associated with lower birth weight and increased risk of adverse outcomes.
format	article
author	Nancy M Fahim Michael K Georgieff Lei Zhang Scott Naisbitt Raghavendra B Rao Terrie E Inder
author_facet	Nancy M Fahim Michael K Georgieff Lei Zhang Scott Naisbitt Raghavendra B Rao Terrie E Inder
author_sort	Nancy M Fahim
title	Endogenous erythropoietin concentrations and association with retinopathy of prematurity and brain injury in preterm infants.
title_short	Endogenous erythropoietin concentrations and association with retinopathy of prematurity and brain injury in preterm infants.
title_full	Endogenous erythropoietin concentrations and association with retinopathy of prematurity and brain injury in preterm infants.
title_fullStr	Endogenous erythropoietin concentrations and association with retinopathy of prematurity and brain injury in preterm infants.
title_full_unstemmed	Endogenous erythropoietin concentrations and association with retinopathy of prematurity and brain injury in preterm infants.
title_sort	endogenous erythropoietin concentrations and association with retinopathy of prematurity and brain injury in preterm infants.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/af5f7d92152745279c7d790a10107abc
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Endogenous erythropoietin concentrations and association with retinopathy of prematurity and brain injury in preterm infants.

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