Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis

<i>Background and Objectives</i>: The present study demonstrates that apart from the well-known toxicity of liposoluble vitamins, some hydrosoluble vitamins may also exert toxicity; thus, routine supplementation with vitamins or ingestion of fortified foods should not be considered harml...

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Autores principales:	Mirela Nicolov, Mioara Cocora, Valentina Buda, Corina Danciu, Adina Octavia Duse, Claudia Watz, Florin Borcan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	water soluble vitamins fat soluble vitamins ADMET profile bioavailability metabolic stability toxicity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/af60b805844d43e2b1d063c04e32839e
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spelling	oai:doaj.org-article:af60b805844d43e2b1d063c04e32839e2021-11-25T18:18:34ZHydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis10.3390/medicina571112041648-91441010-660Xhttps://doaj.org/article/af60b805844d43e2b1d063c04e32839e2021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1204https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and Objectives</i>: The present study demonstrates that apart from the well-known toxicity of liposoluble vitamins, some hydrosoluble vitamins may also exert toxicity; thus, routine supplementation with vitamins or ingestion of fortified foods should not be considered harmless. The study addresses the possible correlations between the physico-chemical properties and the side effects of vitamins when taken in high doses or for a too long a period. <i>Materials and Methods</i>: The FAFDrugs4.0 computational tool was used for computational assessment of the ADMET profile of several hydro- and liposoluble vitamins. <i>Results</i>: ADMET analysis revealed the following major data: vitamin B3 and B13 showed reduced structural complexity; thus, a relative toxicological potential may be exerted. Vitamins B1 and B7 were found to have good oral absorption and thus good bioavailability, while Vitamin B3 was found to have decreased oral absorption. In addition, all of the liposoluble vitamins reflected higher complexity, much greater than most of the potentially therapeutically-proven compounds. <i>Conclusions</i>: The present study emphasizes the importance between the physico-chemical properties of vitamins and their possible toxicological impact.Mirela NicolovMioara CocoraValentina BudaCorina DanciuAdina Octavia DuseClaudia WatzFlorin BorcanMDPI AGarticlewater soluble vitaminsfat soluble vitaminsADMET profilebioavailabilitymetabolic stabilitytoxicityMedicine (General)R5-920ENMedicina, Vol 57, Iss 1204, p 1204 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	water soluble vitamins fat soluble vitamins ADMET profile bioavailability metabolic stability toxicity Medicine (General) R5-920
spellingShingle	water soluble vitamins fat soluble vitamins ADMET profile bioavailability metabolic stability toxicity Medicine (General) R5-920 Mirela Nicolov Mioara Cocora Valentina Buda Corina Danciu Adina Octavia Duse Claudia Watz Florin Borcan Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis
description	<i>Background and Objectives</i>: The present study demonstrates that apart from the well-known toxicity of liposoluble vitamins, some hydrosoluble vitamins may also exert toxicity; thus, routine supplementation with vitamins or ingestion of fortified foods should not be considered harmless. The study addresses the possible correlations between the physico-chemical properties and the side effects of vitamins when taken in high doses or for a too long a period. <i>Materials and Methods</i>: The FAFDrugs4.0 computational tool was used for computational assessment of the ADMET profile of several hydro- and liposoluble vitamins. <i>Results</i>: ADMET analysis revealed the following major data: vitamin B3 and B13 showed reduced structural complexity; thus, a relative toxicological potential may be exerted. Vitamins B1 and B7 were found to have good oral absorption and thus good bioavailability, while Vitamin B3 was found to have decreased oral absorption. In addition, all of the liposoluble vitamins reflected higher complexity, much greater than most of the potentially therapeutically-proven compounds. <i>Conclusions</i>: The present study emphasizes the importance between the physico-chemical properties of vitamins and their possible toxicological impact.
format	article
author	Mirela Nicolov Mioara Cocora Valentina Buda Corina Danciu Adina Octavia Duse Claudia Watz Florin Borcan
author_facet	Mirela Nicolov Mioara Cocora Valentina Buda Corina Danciu Adina Octavia Duse Claudia Watz Florin Borcan
author_sort	Mirela Nicolov
title	Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis
title_short	Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis
title_full	Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis
title_fullStr	Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis
title_full_unstemmed	Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis
title_sort	hydrosoluble and liposoluble vitamins: new perspectives through admet analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/af60b805844d43e2b1d063c04e32839e
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Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis

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