Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin

Skin aging is accompanied by an increase in the number of senescent cells, resulting in various pathological outcomes. These include inflammation, impaired barrier function, and susceptibility to skin disorders such as cancer. Kaempferia parviflora (Thai black ginger), a medicinal plant native to Th...

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Autores principales:	Wannita Klinngam, Phetploy Rungkamoltip, Saowarose Thongin, Jaruwan Joothamongkhon, Phattharachanok Khumkhrong, Mattaka Khongkow, Katawut Namdee, Surapun Tepaamorndech, Puxvadee Chaikul, Mayuree Kanlayavattanakul, Nattaya Lourith, Kitiya Piboonprai, Uracha Ruktanonchai, Udom Asawapirom, Tawin Iempridee
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Polymethoxyflavone Kaempferia parviflora Skin aging Senescence ex vivo Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/af618b7a620a4257bc3836545da73283
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spelling	oai:doaj.org-article:af618b7a620a4257bc3836545da732832021-11-28T04:28:22ZPolymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin0753-332210.1016/j.biopha.2021.112461https://doaj.org/article/af618b7a620a4257bc3836545da732832022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012476https://doaj.org/toc/0753-3322Skin aging is accompanied by an increase in the number of senescent cells, resulting in various pathological outcomes. These include inflammation, impaired barrier function, and susceptibility to skin disorders such as cancer. Kaempferia parviflora (Thai black ginger), a medicinal plant native to Thailand, has been shown to counteract inflammation, cancer, and senescence. This study demonstrates that polymethoxyflavones (5,7-dimethoxyflavone, 5,7,4′-trimethoxyflavone, and 3,5,7,3′,4′-pentamethoxyflavone) purified from K. parviflora rhizomes suppressed cellular senescence, reactive oxygen species, and the senescence-associated secretory phenotype in primary human dermal fibroblasts. In addition, they increased tropocollagen synthesis and alleviated free radical-induced cellular and mitochondrial damage. Moreover, the compounds mitigated chronological aging in a human ex vivo skin model by attenuating senescence and restoring expression of essential components of the extracellular matrix, including collagen type I, fibrillin-1, and hyaluronic acid. Finally, we report that polymethoxyflavones enhanced epidermal thickness and epidermal-dermal stability, while blocking age-related inflammation in skin explants. Our findings support the use of polymethoxyflavones from K. parviflora as natural anti-aging agents, highlighting their potential as active ingredients in cosmeceutical and nutraceutical products.Wannita KlinngamPhetploy RungkamoltipSaowarose ThonginJaruwan JoothamongkhonPhattharachanok KhumkhrongMattaka KhongkowKatawut NamdeeSurapun TepaamorndechPuxvadee ChaikulMayuree KanlayavattanakulNattaya LourithKitiya PiboonpraiUracha RuktanonchaiUdom AsawapiromTawin IemprideeElsevierarticlePolymethoxyflavoneKaempferia parvifloraSkin agingSenescenceex vivoTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112461- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Polymethoxyflavone Kaempferia parviflora Skin aging Senescence ex vivo Therapeutics. Pharmacology RM1-950
spellingShingle	Polymethoxyflavone Kaempferia parviflora Skin aging Senescence ex vivo Therapeutics. Pharmacology RM1-950 Wannita Klinngam Phetploy Rungkamoltip Saowarose Thongin Jaruwan Joothamongkhon Phattharachanok Khumkhrong Mattaka Khongkow Katawut Namdee Surapun Tepaamorndech Puxvadee Chaikul Mayuree Kanlayavattanakul Nattaya Lourith Kitiya Piboonprai Uracha Ruktanonchai Udom Asawapirom Tawin Iempridee Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
description	Skin aging is accompanied by an increase in the number of senescent cells, resulting in various pathological outcomes. These include inflammation, impaired barrier function, and susceptibility to skin disorders such as cancer. Kaempferia parviflora (Thai black ginger), a medicinal plant native to Thailand, has been shown to counteract inflammation, cancer, and senescence. This study demonstrates that polymethoxyflavones (5,7-dimethoxyflavone, 5,7,4′-trimethoxyflavone, and 3,5,7,3′,4′-pentamethoxyflavone) purified from K. parviflora rhizomes suppressed cellular senescence, reactive oxygen species, and the senescence-associated secretory phenotype in primary human dermal fibroblasts. In addition, they increased tropocollagen synthesis and alleviated free radical-induced cellular and mitochondrial damage. Moreover, the compounds mitigated chronological aging in a human ex vivo skin model by attenuating senescence and restoring expression of essential components of the extracellular matrix, including collagen type I, fibrillin-1, and hyaluronic acid. Finally, we report that polymethoxyflavones enhanced epidermal thickness and epidermal-dermal stability, while blocking age-related inflammation in skin explants. Our findings support the use of polymethoxyflavones from K. parviflora as natural anti-aging agents, highlighting their potential as active ingredients in cosmeceutical and nutraceutical products.
format	article
author	Wannita Klinngam Phetploy Rungkamoltip Saowarose Thongin Jaruwan Joothamongkhon Phattharachanok Khumkhrong Mattaka Khongkow Katawut Namdee Surapun Tepaamorndech Puxvadee Chaikul Mayuree Kanlayavattanakul Nattaya Lourith Kitiya Piboonprai Uracha Ruktanonchai Udom Asawapirom Tawin Iempridee
author_facet	Wannita Klinngam Phetploy Rungkamoltip Saowarose Thongin Jaruwan Joothamongkhon Phattharachanok Khumkhrong Mattaka Khongkow Katawut Namdee Surapun Tepaamorndech Puxvadee Chaikul Mayuree Kanlayavattanakul Nattaya Lourith Kitiya Piboonprai Uracha Ruktanonchai Udom Asawapirom Tawin Iempridee
author_sort	Wannita Klinngam
title	Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
title_short	Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
title_full	Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
title_fullStr	Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
title_full_unstemmed	Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
title_sort	polymethoxyflavones from kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/af618b7a620a4257bc3836545da73283
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Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin

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