Fitness consequences of biochemical adaptation in Drosophila melanogaster populations under simultaneous selection for faster pre-adult development and extended lifespan

Abstract In holometabolous insects like Drosophila melanogaster, critical size is an important time point during larval life, for irreversible commitment to metamorphosis. Here, we studied the impact of restricted growth duration in terms of selection for faster pre-adult development in Drosophila m...

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Autores principales:	Khushboo Sharma, Mallikarjun N. Shakarad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/af655a421556434ca089d922418be73d
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spelling	oai:doaj.org-article:af655a421556434ca089d922418be73d2021-12-02T18:50:51ZFitness consequences of biochemical adaptation in Drosophila melanogaster populations under simultaneous selection for faster pre-adult development and extended lifespan10.1038/s41598-021-95951-22045-2322https://doaj.org/article/af655a421556434ca089d922418be73d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95951-2https://doaj.org/toc/2045-2322Abstract In holometabolous insects like Drosophila melanogaster, critical size is an important time point during larval life, for irreversible commitment to metamorphosis. Here, we studied the impact of restricted growth duration in terms of selection for faster pre-adult development in Drosophila melanogaster populations which resulted in the evolution of reduced critical size on adult life history traits. Selection for faster pre-adult development resulted in biochemical adaptation in larval physiology with no compromise in major biomolecules at critical size time point. The flies from the selected populations seem to not only commit to metamorphosis on the attainment of critical size but also seem to channelize resources to reproduction as indicated by similar life-time fecundity of CS and NS flies from selected populations, while the Control CS flies significantly lower life-time fecundity compared to Control NS flies. The flies from selected populations seem to achieve longevity comparable to control flies despite being significantly smaller in size-thus resource constrained due to faster pre-adult development.Khushboo SharmaMallikarjun N. ShakaradNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Khushboo Sharma Mallikarjun N. Shakarad Fitness consequences of biochemical adaptation in Drosophila melanogaster populations under simultaneous selection for faster pre-adult development and extended lifespan
description	Abstract In holometabolous insects like Drosophila melanogaster, critical size is an important time point during larval life, for irreversible commitment to metamorphosis. Here, we studied the impact of restricted growth duration in terms of selection for faster pre-adult development in Drosophila melanogaster populations which resulted in the evolution of reduced critical size on adult life history traits. Selection for faster pre-adult development resulted in biochemical adaptation in larval physiology with no compromise in major biomolecules at critical size time point. The flies from the selected populations seem to not only commit to metamorphosis on the attainment of critical size but also seem to channelize resources to reproduction as indicated by similar life-time fecundity of CS and NS flies from selected populations, while the Control CS flies significantly lower life-time fecundity compared to Control NS flies. The flies from selected populations seem to achieve longevity comparable to control flies despite being significantly smaller in size-thus resource constrained due to faster pre-adult development.
format	article
author	Khushboo Sharma Mallikarjun N. Shakarad
author_facet	Khushboo Sharma Mallikarjun N. Shakarad
author_sort	Khushboo Sharma
title	Fitness consequences of biochemical adaptation in Drosophila melanogaster populations under simultaneous selection for faster pre-adult development and extended lifespan
title_short	Fitness consequences of biochemical adaptation in Drosophila melanogaster populations under simultaneous selection for faster pre-adult development and extended lifespan
title_full	Fitness consequences of biochemical adaptation in Drosophila melanogaster populations under simultaneous selection for faster pre-adult development and extended lifespan
title_fullStr	Fitness consequences of biochemical adaptation in Drosophila melanogaster populations under simultaneous selection for faster pre-adult development and extended lifespan
title_full_unstemmed	Fitness consequences of biochemical adaptation in Drosophila melanogaster populations under simultaneous selection for faster pre-adult development and extended lifespan
title_sort	fitness consequences of biochemical adaptation in drosophila melanogaster populations under simultaneous selection for faster pre-adult development and extended lifespan
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/af655a421556434ca089d922418be73d
work_keys_str_mv	AT khushboosharma fitnessconsequencesofbiochemicaladaptationindrosophilamelanogasterpopulationsundersimultaneousselectionforfasterpreadultdevelopmentandextendedlifespan AT mallikarjunnshakarad fitnessconsequencesofbiochemicaladaptationindrosophilamelanogasterpopulationsundersimultaneousselectionforfasterpreadultdevelopmentandextendedlifespan
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Fitness consequences of biochemical adaptation in Drosophila melanogaster populations under simultaneous selection for faster pre-adult development and extended lifespan

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