L-655,708 does not prevent isoflurane-induced memory deficits in old mice

General anesthesia and increasing age are two main risk factors for postoperative cognitive dysfunction (POCD). Effective agents for the prevention or treatment of POCD are urgently needed. L-655,708, an inverse agonist of α5 subunit-containing γ-aminobutyric acid subtype A (α5GABAA) receptors, can...

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Autores principales:	Gao Teng, Liu Yue, Zhao Zifang, Luo Yuan, Wang Lifang, Wang Yongan, Yin Yiqing
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2019
Materias:	pocd old age gaba inverse agonist l-655,708 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/af65eed44c6745b19227eda22bbd9fc2
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spelling	oai:doaj.org-article:af65eed44c6745b19227eda22bbd9fc22021-12-05T14:11:04ZL-655,708 does not prevent isoflurane-induced memory deficits in old mice2081-693610.1515/tnsci-2019-0032https://doaj.org/article/af65eed44c6745b19227eda22bbd9fc22019-08-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2019-0032https://doaj.org/toc/2081-6936General anesthesia and increasing age are two main risk factors for postoperative cognitive dysfunction (POCD). Effective agents for the prevention or treatment of POCD are urgently needed. L-655,708, an inverse agonist of α5 subunit-containing γ-aminobutyric acid subtype A (α5GABAA) receptors, can prevent anesthesia-induced memory deficits in young animals. However, there is a lack of evidence of its efficacy in old animals.Gao TengLiu YueZhao ZifangLuo YuanWang LifangWang YonganYin YiqingDe Gruyterarticlepocdold agegabainverse agonistl-655,708Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 10, Iss 1, Pp 180-186 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	pocd old age gaba inverse agonist l-655,708 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	pocd old age gaba inverse agonist l-655,708 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Gao Teng Liu Yue Zhao Zifang Luo Yuan Wang Lifang Wang Yongan Yin Yiqing L-655,708 does not prevent isoflurane-induced memory deficits in old mice
description	General anesthesia and increasing age are two main risk factors for postoperative cognitive dysfunction (POCD). Effective agents for the prevention or treatment of POCD are urgently needed. L-655,708, an inverse agonist of α5 subunit-containing γ-aminobutyric acid subtype A (α5GABAA) receptors, can prevent anesthesia-induced memory deficits in young animals. However, there is a lack of evidence of its efficacy in old animals.
format	article
author	Gao Teng Liu Yue Zhao Zifang Luo Yuan Wang Lifang Wang Yongan Yin Yiqing
author_facet	Gao Teng Liu Yue Zhao Zifang Luo Yuan Wang Lifang Wang Yongan Yin Yiqing
author_sort	Gao Teng
title	L-655,708 does not prevent isoflurane-induced memory deficits in old mice
title_short	L-655,708 does not prevent isoflurane-induced memory deficits in old mice
title_full	L-655,708 does not prevent isoflurane-induced memory deficits in old mice
title_fullStr	L-655,708 does not prevent isoflurane-induced memory deficits in old mice
title_full_unstemmed	L-655,708 does not prevent isoflurane-induced memory deficits in old mice
title_sort	l-655,708 does not prevent isoflurane-induced memory deficits in old mice
publisher	De Gruyter
publishDate	2019
url	https://doaj.org/article/af65eed44c6745b19227eda22bbd9fc2
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L-655,708 does not prevent isoflurane-induced memory deficits in old mice

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