Human whole genome sequencing in South Africa
Abstract The advent and evolution of next generation sequencing has considerably impacted genomic research. Until recently, South African researchers were unable to access affordable platforms capable of human whole genome sequencing locally and DNA samples had to be exported. Here we report the who...
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Nature Portfolio
2021
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oai:doaj.org-article:af67a373284c4ea18260be21e84c3bde2021-12-02T14:12:41ZHuman whole genome sequencing in South Africa10.1038/s41598-020-79794-x2045-2322https://doaj.org/article/af67a373284c4ea18260be21e84c3bde2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79794-xhttps://doaj.org/toc/2045-2322Abstract The advent and evolution of next generation sequencing has considerably impacted genomic research. Until recently, South African researchers were unable to access affordable platforms capable of human whole genome sequencing locally and DNA samples had to be exported. Here we report the whole genome sequences of the first six human DNA samples sequenced and analysed at the South African Medical Research Council’s Genomics Centre. We demonstrate that the data obtained is of high quality, with an average sequencing depth of 36.41, and that the output is comparable to data generated internationally on a similar platform. The Genomics Centre creates an environment where African researchers are able to access world class facilities, increasing local capacity to sequence whole genomes as well as store and analyse the data.Brigitte GlanzmannTracey JoosteSamira GhoorRichard GordonRizwana MiaJun MaoHao LiPatrick CharlsCraig DoumanMaritha J. KotzeArmand V. PeetersGlaudina LootsMonika EsserCaroline T. TiemessenRobert J. WilkinsonJohan LouwGlenda GrayRobin M. WarrenMarlo MöllerCraig KinnearNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Brigitte Glanzmann Tracey Jooste Samira Ghoor Richard Gordon Rizwana Mia Jun Mao Hao Li Patrick Charls Craig Douman Maritha J. Kotze Armand V. Peeters Glaudina Loots Monika Esser Caroline T. Tiemessen Robert J. Wilkinson Johan Louw Glenda Gray Robin M. Warren Marlo Möller Craig Kinnear Human whole genome sequencing in South Africa |
| description |
Abstract The advent and evolution of next generation sequencing has considerably impacted genomic research. Until recently, South African researchers were unable to access affordable platforms capable of human whole genome sequencing locally and DNA samples had to be exported. Here we report the whole genome sequences of the first six human DNA samples sequenced and analysed at the South African Medical Research Council’s Genomics Centre. We demonstrate that the data obtained is of high quality, with an average sequencing depth of 36.41, and that the output is comparable to data generated internationally on a similar platform. The Genomics Centre creates an environment where African researchers are able to access world class facilities, increasing local capacity to sequence whole genomes as well as store and analyse the data. |
| format |
article |
| author |
Brigitte Glanzmann Tracey Jooste Samira Ghoor Richard Gordon Rizwana Mia Jun Mao Hao Li Patrick Charls Craig Douman Maritha J. Kotze Armand V. Peeters Glaudina Loots Monika Esser Caroline T. Tiemessen Robert J. Wilkinson Johan Louw Glenda Gray Robin M. Warren Marlo Möller Craig Kinnear |
| author_facet |
Brigitte Glanzmann Tracey Jooste Samira Ghoor Richard Gordon Rizwana Mia Jun Mao Hao Li Patrick Charls Craig Douman Maritha J. Kotze Armand V. Peeters Glaudina Loots Monika Esser Caroline T. Tiemessen Robert J. Wilkinson Johan Louw Glenda Gray Robin M. Warren Marlo Möller Craig Kinnear |
| author_sort |
Brigitte Glanzmann |
| title |
Human whole genome sequencing in South Africa |
| title_short |
Human whole genome sequencing in South Africa |
| title_full |
Human whole genome sequencing in South Africa |
| title_fullStr |
Human whole genome sequencing in South Africa |
| title_full_unstemmed |
Human whole genome sequencing in South Africa |
| title_sort |
human whole genome sequencing in south africa |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/af67a373284c4ea18260be21e84c3bde |
| work_keys_str_mv |
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