3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity

Gopal et al. present a high-throughput platform for analysing the cytotoxicity of various combination therapies against established cancer cell lines, focusing especially on NK cell-mediated cytotoxicity. The presented method is reported to successfully mimic the tumour microenvironment and demonstr...

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Autores principales:	Sneha Gopal, Seok-Joon Kwon, Bosung Ku, Dong Woo Lee, Jungeun Kim, Jonathan S. Dordick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/af67cea50a174afea27e38c42066450c
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spelling	oai:doaj.org-article:af67cea50a174afea27e38c42066450c2021-12-02T17:55:11Z3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity10.1038/s42003-021-02417-22399-3642https://doaj.org/article/af67cea50a174afea27e38c42066450c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02417-2https://doaj.org/toc/2399-3642Gopal et al. present a high-throughput platform for analysing the cytotoxicity of various combination therapies against established cancer cell lines, focusing especially on NK cell-mediated cytotoxicity. The presented method is reported to successfully mimic the tumour microenvironment and demonstrates NK cell-mediated cell cytotoxicity using small molecule chemotherapeutic drugs in combination with monoclonal antibodies.Sneha GopalSeok-Joon KwonBosung KuDong Woo LeeJungeun KimJonathan S. DordickNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sneha Gopal Seok-Joon Kwon Bosung Ku Dong Woo Lee Jungeun Kim Jonathan S. Dordick 3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity
description	Gopal et al. present a high-throughput platform for analysing the cytotoxicity of various combination therapies against established cancer cell lines, focusing especially on NK cell-mediated cytotoxicity. The presented method is reported to successfully mimic the tumour microenvironment and demonstrates NK cell-mediated cell cytotoxicity using small molecule chemotherapeutic drugs in combination with monoclonal antibodies.
format	article
author	Sneha Gopal Seok-Joon Kwon Bosung Ku Dong Woo Lee Jungeun Kim Jonathan S. Dordick
author_facet	Sneha Gopal Seok-Joon Kwon Bosung Ku Dong Woo Lee Jungeun Kim Jonathan S. Dordick
author_sort	Sneha Gopal
title	3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity
title_short	3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity
title_full	3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity
title_fullStr	3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity
title_full_unstemmed	3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity
title_sort	3d tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/af67cea50a174afea27e38c42066450c
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3D tumor spheroid microarray for high-throughput, high-content natural killer cell-mediated cytotoxicity

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