PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma

PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma

Abstract Poor trastuzumab (Tmab) response of patients with human epidermal growth factor receptor 2-overexpressing gastric or gastroesophageal junction adenocarcinoma (HER2-GEA) is associated with the inhibition of phosphatase and tensin homolog (PTEN) expression. In this multicenter, retrospective...

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Main Authors: Daiju Yokoyama, Shigeo Hisamori, Yasunori Deguchi, Tatsuto Nishigori, Hiroshi Okabe, Seiichiro Kanaya, Dai Manaka, Yoshio Kadokawa, Hiroaki Hata, Sachiko Minamiguchi, Shigeru Tsunoda, Kazutaka Obama, Yoshiharu Sakai
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/af698eef3b3f4acea1b3b7bfb6a09a48
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https://doaj.org/article/af698eef3b3f4acea1b3b7bfb6a09a48

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