Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells

Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells

Seguin et al demonstrated in glioblastoma patient-derived stem cells that a subset of glioblastoma tumours is dependent on macropinocytosis mediated survival through a Galectin-3/RAB10/beta 1 integrin axis. They used both genetic and pharmacologic inhibition of Galectin-3 in vivo and in vitro to ide...

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Autores principales: Laetitia Seguin, Soline Odouard, Francesca Corlazzoli, Sarah Al Haddad, Laurine Moindrot, Marta Calvo Tardón, Mayra Yebra, Alexey Koval, Eliana Marinari, Viviane Bes, Alexandre Guérin, Mathilde Allard, Sten Ilmjärv, Vladimir L. Katanaev, Paul R. Walker, Karl-Heinz Krause, Valérie Dutoit, Jann N. Sarkaria, Pierre-Yves Dietrich, Érika Cosset
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/af6a9382a80a4f38a4b6f252cbc7ee7f
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spelling oai:doaj.org-article:af6a9382a80a4f38a4b6f252cbc7ee7f2021-12-02T17:47:03ZMacropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells10.1038/s42003-021-02258-z2399-3642https://doaj.org/article/af6a9382a80a4f38a4b6f252cbc7ee7f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02258-zhttps://doaj.org/toc/2399-3642Seguin et al demonstrated in glioblastoma patient-derived stem cells that a subset of glioblastoma tumours is dependent on macropinocytosis mediated survival through a Galectin-3/RAB10/beta 1 integrin axis. They used both genetic and pharmacologic inhibition of Galectin-3 in vivo and in vitro to identify underlying mechanisms and define a Galectin-3/macropinocytosis molecular signature, which could inform the development of anti-tumour therapeutic strategies.Laetitia SeguinSoline OdouardFrancesca CorlazzoliSarah Al HaddadLaurine MoindrotMarta Calvo TardónMayra YebraAlexey KovalEliana MarinariViviane BesAlexandre GuérinMathilde AllardSten IlmjärvVladimir L. KatanaevPaul R. WalkerKarl-Heinz KrauseValérie DutoitJann N. SarkariaPierre-Yves DietrichÉrika CossetNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Laetitia Seguin
Soline Odouard
Francesca Corlazzoli
Sarah Al Haddad
Laurine Moindrot
Marta Calvo Tardón
Mayra Yebra
Alexey Koval
Eliana Marinari
Viviane Bes
Alexandre Guérin
Mathilde Allard
Sten Ilmjärv
Vladimir L. Katanaev
Paul R. Walker
Karl-Heinz Krause
Valérie Dutoit
Jann N. Sarkaria
Pierre-Yves Dietrich
Érika Cosset
Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells
description Seguin et al demonstrated in glioblastoma patient-derived stem cells that a subset of glioblastoma tumours is dependent on macropinocytosis mediated survival through a Galectin-3/RAB10/beta 1 integrin axis. They used both genetic and pharmacologic inhibition of Galectin-3 in vivo and in vitro to identify underlying mechanisms and define a Galectin-3/macropinocytosis molecular signature, which could inform the development of anti-tumour therapeutic strategies.
format article
author Laetitia Seguin
Soline Odouard
Francesca Corlazzoli
Sarah Al Haddad
Laurine Moindrot
Marta Calvo Tardón
Mayra Yebra
Alexey Koval
Eliana Marinari
Viviane Bes
Alexandre Guérin
Mathilde Allard
Sten Ilmjärv
Vladimir L. Katanaev
Paul R. Walker
Karl-Heinz Krause
Valérie Dutoit
Jann N. Sarkaria
Pierre-Yves Dietrich
Érika Cosset
author_facet Laetitia Seguin
Soline Odouard
Francesca Corlazzoli
Sarah Al Haddad
Laurine Moindrot
Marta Calvo Tardón
Mayra Yebra
Alexey Koval
Eliana Marinari
Viviane Bes
Alexandre Guérin
Mathilde Allard
Sten Ilmjärv
Vladimir L. Katanaev
Paul R. Walker
Karl-Heinz Krause
Valérie Dutoit
Jann N. Sarkaria
Pierre-Yves Dietrich
Érika Cosset
author_sort Laetitia Seguin
title Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells
title_short Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells
title_full Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells
title_fullStr Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells
title_full_unstemmed Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells
title_sort macropinocytosis requires gal-3 in a subset of patient-derived glioblastoma stem cells
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/af6a9382a80a4f38a4b6f252cbc7ee7f
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