Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells

Macropinocytosis requires Gal-3 in a subset of patient-derived glioblastoma stem cells

Seguin et al demonstrated in glioblastoma patient-derived stem cells that a subset of glioblastoma tumours is dependent on macropinocytosis mediated survival through a Galectin-3/RAB10/beta 1 integrin axis. They used both genetic and pharmacologic inhibition of Galectin-3 in vivo and in vitro to ide...

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Bibliographic Details
Main Authors: Laetitia Seguin, Soline Odouard, Francesca Corlazzoli, Sarah Al Haddad, Laurine Moindrot, Marta Calvo Tardón, Mayra Yebra, Alexey Koval, Eliana Marinari, Viviane Bes, Alexandre Guérin, Mathilde Allard, Sten Ilmjärv, Vladimir L. Katanaev, Paul R. Walker, Karl-Heinz Krause, Valérie Dutoit, Jann N. Sarkaria, Pierre-Yves Dietrich, Érika Cosset
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/af6a9382a80a4f38a4b6f252cbc7ee7f
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