Movement disorder profile and treatment outcomes in a one-year study of patients with schizophrenia

Lei Chen, Haya Ascher-Svanum, Anthony Lawson, Virginia L Stauffer, Allen Nyhuis, Virginia Haynes, Kory Schuh, Bruce J KinonEli Lilly and Company, Indianapolis, IN, USABackground: This study identified subgroups of patients with schizophrenia who differed on their movement disorder profile and compar...

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Autores principales:	Chen L, Ascher-Svanum H, Lawson A, Stauffer VL, Nyhuis A, Haynes V, Schuh K, Kinon BJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/af6c890d7ccc431bb472958c0c9517b2
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spelling	oai:doaj.org-article:af6c890d7ccc431bb472958c0c9517b22021-12-02T04:57:13ZMovement disorder profile and treatment outcomes in a one-year study of patients with schizophrenia1176-63281178-2021https://doaj.org/article/af6c890d7ccc431bb472958c0c9517b22013-06-01T00:00:00Zhttp://www.dovepress.com/movement-disorder-profile-and-treatment-outcomes-in-a-one-year-study-o-a13345https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Lei Chen, Haya Ascher-Svanum, Anthony Lawson, Virginia L Stauffer, Allen Nyhuis, Virginia Haynes, Kory Schuh, Bruce J KinonEli Lilly and Company, Indianapolis, IN, USABackground: This study identified subgroups of patients with schizophrenia who differed on their movement disorder profile and compared their treatment outcomes.Methods: Data from a randomized, open-label, one-year study of patients with schizophrenia who were treated with antipsychotics in usual clinical care settings were analyzed (n = 640). Five measures of movement disorder were incorporated into a single Movement Disorder Index (MDI). Subgroups that differed in their movement disorder profile over the one-year study period were compared on clinical and functional outcomes.Results: Three subgroups were identified: a worsening of MDI in 15% of patients, an improvement in 33%, and no change in 53%. Compared with the other two subgroups, the MDI-worsened subgroup had poorer symptom improvement measured by the Positive and Negative Syndrome Scale (PANSS) total score (mean changes of −11.0, −18.4, and −16.8 for the patients who had a worsening of MDI, no change, and an improvement, respectively), poorer symptom improvement on the PANSS positive and anxiety/depression subscale scores, worsening on the 36-Item Short Form Health Survey (SF-36) physical component summary score, and a higher rate of hospitalization (P < 0.05).Conclusion: Patients with schizophrenia who experience worsening of their MDI score appear to have poorer clinical and functional outcomes, suggesting that such worsening may be a marker of poorer prognosis.Keywords: schizophrenia, treatment outcome, movement disorderChen LAscher-Svanum HLawson AStauffer VLNyhuis AHaynes VSchuh KKinon BJDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 815-822 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chen L Ascher-Svanum H Lawson A Stauffer VL Nyhuis A Haynes V Schuh K Kinon BJ Movement disorder profile and treatment outcomes in a one-year study of patients with schizophrenia
description	Lei Chen, Haya Ascher-Svanum, Anthony Lawson, Virginia L Stauffer, Allen Nyhuis, Virginia Haynes, Kory Schuh, Bruce J KinonEli Lilly and Company, Indianapolis, IN, USABackground: This study identified subgroups of patients with schizophrenia who differed on their movement disorder profile and compared their treatment outcomes.Methods: Data from a randomized, open-label, one-year study of patients with schizophrenia who were treated with antipsychotics in usual clinical care settings were analyzed (n = 640). Five measures of movement disorder were incorporated into a single Movement Disorder Index (MDI). Subgroups that differed in their movement disorder profile over the one-year study period were compared on clinical and functional outcomes.Results: Three subgroups were identified: a worsening of MDI in 15% of patients, an improvement in 33%, and no change in 53%. Compared with the other two subgroups, the MDI-worsened subgroup had poorer symptom improvement measured by the Positive and Negative Syndrome Scale (PANSS) total score (mean changes of −11.0, −18.4, and −16.8 for the patients who had a worsening of MDI, no change, and an improvement, respectively), poorer symptom improvement on the PANSS positive and anxiety/depression subscale scores, worsening on the 36-Item Short Form Health Survey (SF-36) physical component summary score, and a higher rate of hospitalization (P < 0.05).Conclusion: Patients with schizophrenia who experience worsening of their MDI score appear to have poorer clinical and functional outcomes, suggesting that such worsening may be a marker of poorer prognosis.Keywords: schizophrenia, treatment outcome, movement disorder
format	article
author	Chen L Ascher-Svanum H Lawson A Stauffer VL Nyhuis A Haynes V Schuh K Kinon BJ
author_facet	Chen L Ascher-Svanum H Lawson A Stauffer VL Nyhuis A Haynes V Schuh K Kinon BJ
author_sort	Chen L
title	Movement disorder profile and treatment outcomes in a one-year study of patients with schizophrenia
title_short	Movement disorder profile and treatment outcomes in a one-year study of patients with schizophrenia
title_full	Movement disorder profile and treatment outcomes in a one-year study of patients with schizophrenia
title_fullStr	Movement disorder profile and treatment outcomes in a one-year study of patients with schizophrenia
title_full_unstemmed	Movement disorder profile and treatment outcomes in a one-year study of patients with schizophrenia
title_sort	movement disorder profile and treatment outcomes in a one-year study of patients with schizophrenia
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/af6c890d7ccc431bb472958c0c9517b2
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Movement disorder profile and treatment outcomes in a one-year study of patients with schizophrenia

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