Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing

Cytidine base editors are powerful tools for making subtle genome alterations. Here the authors analyse edited human iPSCs with whole genome sequencing and reveal the spectrum of off-target effects.

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Autores principales:	Erica McGrath, Hyunsu Shin, Linyi Zhang, Je-Nie Phue, Wells W. Wu, Rong-Fong Shen, Yoon-Young Jang, Javier Revollo, Zhaohui Ye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af712862da014df4afe9e07f5f556c66
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spelling	oai:doaj.org-article:af712862da014df4afe9e07f5f556c662021-12-02T15:35:06ZTargeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing10.1038/s41467-019-13342-82041-1723https://doaj.org/article/af712862da014df4afe9e07f5f556c662019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13342-8https://doaj.org/toc/2041-1723Cytidine base editors are powerful tools for making subtle genome alterations. Here the authors analyse edited human iPSCs with whole genome sequencing and reveal the spectrum of off-target effects.Erica McGrathHyunsu ShinLinyi ZhangJe-Nie PhueWells W. WuRong-Fong ShenYoon-Young JangJavier RevolloZhaohui YeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erica McGrath Hyunsu Shin Linyi Zhang Je-Nie Phue Wells W. Wu Rong-Fong Shen Yoon-Young Jang Javier Revollo Zhaohui Ye Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
description	Cytidine base editors are powerful tools for making subtle genome alterations. Here the authors analyse edited human iPSCs with whole genome sequencing and reveal the spectrum of off-target effects.
format	article
author	Erica McGrath Hyunsu Shin Linyi Zhang Je-Nie Phue Wells W. Wu Rong-Fong Shen Yoon-Young Jang Javier Revollo Zhaohui Ye
author_facet	Erica McGrath Hyunsu Shin Linyi Zhang Je-Nie Phue Wells W. Wu Rong-Fong Shen Yoon-Young Jang Javier Revollo Zhaohui Ye
author_sort	Erica McGrath
title	Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
title_short	Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
title_full	Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
title_fullStr	Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
title_full_unstemmed	Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
title_sort	targeting specificity of apobec-based cytosine base editor in human ipscs determined by whole genome sequencing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/af712862da014df4afe9e07f5f556c66
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Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing

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