Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

Multiple myeloma is a cancer of the plasma cells, and the complete aetiology of the disease is still unclear. Here the authors perform an additional GWAS analysis followed by a meta-analysis with existing GWAS and replication genotyping and identify 6 novel risk loci and utilise gene expression, epi...

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Autores principales:	Molly Went, Amit Sud, Asta Försti, Britt-Marie Halvarsson, Niels Weinhold, Scott Kimber, Mark van Duin, Gudmar Thorleifsson, Amy Holroyd, David C. Johnson, Ni Li, Giulia Orlando, Philip J. Law, Mina Ali, Bowang Chen, Jonathan S. Mitchell, Daniel F. Gudbjartsson, Rowan Kuiper, Owen W. Stephens, Uta Bertsch, Peter Broderick, Chiara Campo, Obul R Bandapalli, Hermann Einsele, Walter A. Gregory, Urban Gullberg, Jens Hillengass, Per Hoffmann, Graham H. Jackson, Karl-Heinz Jöckel, Ellinor Johnsson, Sigurður Y. Kristinsson, Ulf-Henrik Mellqvist, Hareth Nahi, Douglas Easton, Paul Pharoah, Alison Dunning, Julian Peto, Federico Canzian, Anthony Swerdlow, Rosalind A. Eeles, ZSofia Kote-Jarai, Kenneth Muir, Nora Pashayan, Jolanta Nickel, Markus M. Nöthen, Thorunn Rafnar, Fiona M. Ross, Miguel Inacio da Silva Filho, Hauke Thomsen, Ingemar Turesson, Annette Vangsted, Niels Frost Andersen, Anders Waage, Brian A. Walker, Anna-Karin Wihlborg, Annemiek Broyl, Faith E. Davies, Unnur Thorsteinsdottir, Christian Langer, Markus Hansson, Hartmut Goldschmidt, Martin Kaiser, Pieter Sonneveld, Kari Stefansson, Gareth J. Morgan, Kari Hemminki, Björn Nilsson, Richard S. Houlston, The PRACTICAL consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af73d8d01835421aac1fd29b48af6093
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spelling	oai:doaj.org-article:af73d8d01835421aac1fd29b48af60932021-12-02T16:56:35ZIdentification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma10.1038/s41467-018-04989-w2041-1723https://doaj.org/article/af73d8d01835421aac1fd29b48af60932018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04989-whttps://doaj.org/toc/2041-1723Multiple myeloma is a cancer of the plasma cells, and the complete aetiology of the disease is still unclear. Here the authors perform an additional GWAS analysis followed by a meta-analysis with existing GWAS and replication genotyping and identify 6 novel risk loci and utilise gene expression, epigenetic profiling and in situ Hi-C data to further our understanding of MM susceptibility.Molly WentAmit SudAsta FörstiBritt-Marie HalvarssonNiels WeinholdScott KimberMark van DuinGudmar ThorleifssonAmy HolroydDavid C. JohnsonNi LiGiulia OrlandoPhilip J. LawMina AliBowang ChenJonathan S. MitchellDaniel F. GudbjartssonRowan KuiperOwen W. StephensUta BertschPeter BroderickChiara CampoObul R BandapalliHermann EinseleWalter A. GregoryUrban GullbergJens HillengassPer HoffmannGraham H. JacksonKarl-Heinz JöckelEllinor JohnssonSigurður Y. KristinssonUlf-Henrik MellqvistHareth NahiDouglas EastonPaul PharoahAlison DunningJulian PetoFederico CanzianAnthony SwerdlowRosalind A. EelesZSofia Kote-JaraiKenneth MuirNora PashayanJolanta NickelMarkus M. NöthenThorunn RafnarFiona M. RossMiguel Inacio da Silva FilhoHauke ThomsenIngemar TuressonAnnette VangstedNiels Frost AndersenAnders WaageBrian A. WalkerAnna-Karin WihlborgAnnemiek BroylFaith E. DaviesUnnur ThorsteinsdottirChristian LangerMarkus HanssonHartmut GoldschmidtMartin KaiserPieter SonneveldKari StefanssonGareth J. MorganKari HemminkiBjörn NilssonRichard S. HoulstonThe PRACTICAL consortiumNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Molly Went Amit Sud Asta Försti Britt-Marie Halvarsson Niels Weinhold Scott Kimber Mark van Duin Gudmar Thorleifsson Amy Holroyd David C. Johnson Ni Li Giulia Orlando Philip J. Law Mina Ali Bowang Chen Jonathan S. Mitchell Daniel F. Gudbjartsson Rowan Kuiper Owen W. Stephens Uta Bertsch Peter Broderick Chiara Campo Obul R Bandapalli Hermann Einsele Walter A. Gregory Urban Gullberg Jens Hillengass Per Hoffmann Graham H. Jackson Karl-Heinz Jöckel Ellinor Johnsson Sigurður Y. Kristinsson Ulf-Henrik Mellqvist Hareth Nahi Douglas Easton Paul Pharoah Alison Dunning Julian Peto Federico Canzian Anthony Swerdlow Rosalind A. Eeles ZSofia Kote-Jarai Kenneth Muir Nora Pashayan Jolanta Nickel Markus M. Nöthen Thorunn Rafnar Fiona M. Ross Miguel Inacio da Silva Filho Hauke Thomsen Ingemar Turesson Annette Vangsted Niels Frost Andersen Anders Waage Brian A. Walker Anna-Karin Wihlborg Annemiek Broyl Faith E. Davies Unnur Thorsteinsdottir Christian Langer Markus Hansson Hartmut Goldschmidt Martin Kaiser Pieter Sonneveld Kari Stefansson Gareth J. Morgan Kari Hemminki Björn Nilsson Richard S. Houlston The PRACTICAL consortium Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
description	Multiple myeloma is a cancer of the plasma cells, and the complete aetiology of the disease is still unclear. Here the authors perform an additional GWAS analysis followed by a meta-analysis with existing GWAS and replication genotyping and identify 6 novel risk loci and utilise gene expression, epigenetic profiling and in situ Hi-C data to further our understanding of MM susceptibility.
format	article
author	Molly Went Amit Sud Asta Försti Britt-Marie Halvarsson Niels Weinhold Scott Kimber Mark van Duin Gudmar Thorleifsson Amy Holroyd David C. Johnson Ni Li Giulia Orlando Philip J. Law Mina Ali Bowang Chen Jonathan S. Mitchell Daniel F. Gudbjartsson Rowan Kuiper Owen W. Stephens Uta Bertsch Peter Broderick Chiara Campo Obul R Bandapalli Hermann Einsele Walter A. Gregory Urban Gullberg Jens Hillengass Per Hoffmann Graham H. Jackson Karl-Heinz Jöckel Ellinor Johnsson Sigurður Y. Kristinsson Ulf-Henrik Mellqvist Hareth Nahi Douglas Easton Paul Pharoah Alison Dunning Julian Peto Federico Canzian Anthony Swerdlow Rosalind A. Eeles ZSofia Kote-Jarai Kenneth Muir Nora Pashayan Jolanta Nickel Markus M. Nöthen Thorunn Rafnar Fiona M. Ross Miguel Inacio da Silva Filho Hauke Thomsen Ingemar Turesson Annette Vangsted Niels Frost Andersen Anders Waage Brian A. Walker Anna-Karin Wihlborg Annemiek Broyl Faith E. Davies Unnur Thorsteinsdottir Christian Langer Markus Hansson Hartmut Goldschmidt Martin Kaiser Pieter Sonneveld Kari Stefansson Gareth J. Morgan Kari Hemminki Björn Nilsson Richard S. Houlston The PRACTICAL consortium
author_facet	Molly Went Amit Sud Asta Försti Britt-Marie Halvarsson Niels Weinhold Scott Kimber Mark van Duin Gudmar Thorleifsson Amy Holroyd David C. Johnson Ni Li Giulia Orlando Philip J. Law Mina Ali Bowang Chen Jonathan S. Mitchell Daniel F. Gudbjartsson Rowan Kuiper Owen W. Stephens Uta Bertsch Peter Broderick Chiara Campo Obul R Bandapalli Hermann Einsele Walter A. Gregory Urban Gullberg Jens Hillengass Per Hoffmann Graham H. Jackson Karl-Heinz Jöckel Ellinor Johnsson Sigurður Y. Kristinsson Ulf-Henrik Mellqvist Hareth Nahi Douglas Easton Paul Pharoah Alison Dunning Julian Peto Federico Canzian Anthony Swerdlow Rosalind A. Eeles ZSofia Kote-Jarai Kenneth Muir Nora Pashayan Jolanta Nickel Markus M. Nöthen Thorunn Rafnar Fiona M. Ross Miguel Inacio da Silva Filho Hauke Thomsen Ingemar Turesson Annette Vangsted Niels Frost Andersen Anders Waage Brian A. Walker Anna-Karin Wihlborg Annemiek Broyl Faith E. Davies Unnur Thorsteinsdottir Christian Langer Markus Hansson Hartmut Goldschmidt Martin Kaiser Pieter Sonneveld Kari Stefansson Gareth J. Morgan Kari Hemminki Björn Nilsson Richard S. Houlston The PRACTICAL consortium
author_sort	Molly Went
title	Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
title_short	Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
title_full	Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
title_fullStr	Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
title_full_unstemmed	Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
title_sort	identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/af73d8d01835421aac1fd29b48af6093
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Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

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