Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.

<h4>Background</h4>Neutrophils are important for host innate immune defense and mediate inflammatory responses. Pulmonary tuberculosis (PTB) is associated with increased neutrophil granular protein (NGP) levels in the circulation. However, the systemic levels of neutrophil granular prote...

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Autores principales:	Gokul Raj Kathamuthu, Kadar Moideen, Rathinam Sridhar, Dhanaraj Baskaran, Subash Babu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/af77471d575340ebb97fcda7bce0e3f2
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spelling	oai:doaj.org-article:af77471d575340ebb97fcda7bce0e3f22021-12-02T20:10:19ZReduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.1932-620310.1371/journal.pone.0253534https://doaj.org/article/af77471d575340ebb97fcda7bce0e3f22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253534https://doaj.org/toc/1932-6203<h4>Background</h4>Neutrophils are important for host innate immune defense and mediate inflammatory responses. Pulmonary tuberculosis (PTB) is associated with increased neutrophil granular protein (NGP) levels in the circulation. However, the systemic levels of neutrophil granular proteins were not examined in tuberculous lymphadenitis (TBL) disease.<h4>Methods</h4>We measured the systemic levels of NGP (myeloperoxidase [MPO], elastase and proteinase 3 [PRTN3]) in TBL and compared them to latent tuberculosis (LTB) and healthy control (HC) individuals. We also measured the pre-treatment (Pre-T) and post-treatment (Post-T) systemic levels of neutrophil granular proteins in TBL individuals upon anti-tuberculosis treatment (ATT) completion. In addition, we studied the correlation and discriminatory ability of NGPs using receiver operating characteristic (ROC) analysis.<h4>Results</h4>Our data suggests that systemic levels of NGPs (MPO, PRTN3, elastase) were significantly reduced in TBL individuals compared to LTB and HC individuals. Similarly, after ATT, the plasma levels of MPO and elastase but not PRTN3 were significantly elevated compared to pre-treatment levels. NGPs (except PRTN3) were positively correlated with absolute neutrophil count of TBL, LTB and HC individuals. Further, NGPs were able to significantly discriminate TBL from LTB and HC individuals.<h4>Conclusion</h4>Hence, we conclude reduced neutrophil granular protein levels might be associated with disease pathogenesis in TBL.Gokul Raj KathamuthuKadar MoideenRathinam SridharDhanaraj BaskaranSubash BabuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253534 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gokul Raj Kathamuthu Kadar Moideen Rathinam Sridhar Dhanaraj Baskaran Subash Babu Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.
description	<h4>Background</h4>Neutrophils are important for host innate immune defense and mediate inflammatory responses. Pulmonary tuberculosis (PTB) is associated with increased neutrophil granular protein (NGP) levels in the circulation. However, the systemic levels of neutrophil granular proteins were not examined in tuberculous lymphadenitis (TBL) disease.<h4>Methods</h4>We measured the systemic levels of NGP (myeloperoxidase [MPO], elastase and proteinase 3 [PRTN3]) in TBL and compared them to latent tuberculosis (LTB) and healthy control (HC) individuals. We also measured the pre-treatment (Pre-T) and post-treatment (Post-T) systemic levels of neutrophil granular proteins in TBL individuals upon anti-tuberculosis treatment (ATT) completion. In addition, we studied the correlation and discriminatory ability of NGPs using receiver operating characteristic (ROC) analysis.<h4>Results</h4>Our data suggests that systemic levels of NGPs (MPO, PRTN3, elastase) were significantly reduced in TBL individuals compared to LTB and HC individuals. Similarly, after ATT, the plasma levels of MPO and elastase but not PRTN3 were significantly elevated compared to pre-treatment levels. NGPs (except PRTN3) were positively correlated with absolute neutrophil count of TBL, LTB and HC individuals. Further, NGPs were able to significantly discriminate TBL from LTB and HC individuals.<h4>Conclusion</h4>Hence, we conclude reduced neutrophil granular protein levels might be associated with disease pathogenesis in TBL.
format	article
author	Gokul Raj Kathamuthu Kadar Moideen Rathinam Sridhar Dhanaraj Baskaran Subash Babu
author_facet	Gokul Raj Kathamuthu Kadar Moideen Rathinam Sridhar Dhanaraj Baskaran Subash Babu
author_sort	Gokul Raj Kathamuthu
title	Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.
title_short	Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.
title_full	Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.
title_fullStr	Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.
title_full_unstemmed	Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.
title_sort	reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/af77471d575340ebb97fcda7bce0e3f2
work_keys_str_mv	AT gokulrajkathamuthu reducedneutrophilgranularproteinsandposttreatmentmodulationintuberculouslymphadenitis AT kadarmoideen reducedneutrophilgranularproteinsandposttreatmentmodulationintuberculouslymphadenitis AT rathinamsridhar reducedneutrophilgranularproteinsandposttreatmentmodulationintuberculouslymphadenitis AT dhanarajbaskaran reducedneutrophilgranularproteinsandposttreatmentmodulationintuberculouslymphadenitis AT subashbabu reducedneutrophilgranularproteinsandposttreatmentmodulationintuberculouslymphadenitis
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Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.

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