AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis

Regeneration after injury in the Drosophila intestine involves early activation of intestinal stem cells (ISCs) and subsequent return to quiescence. Here the authors show that return to quiescence by ISCs involves BMP Type I receptor Tkv protein stabilization along with AWD mediated internalization...

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Autores principales:	Xiaoyu Tracy Cai, Hongjie Li, Abu Safyan, Jennifer Gawlik, George Pyrowolakis, Heinrich Jasper
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af7a2653f02440a7a060265fa985a893
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spelling	oai:doaj.org-article:af7a2653f02440a7a060265fa985a8932021-12-02T14:39:00ZAWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis10.1038/s41467-019-10926-22041-1723https://doaj.org/article/af7a2653f02440a7a060265fa985a8932019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10926-2https://doaj.org/toc/2041-1723Regeneration after injury in the Drosophila intestine involves early activation of intestinal stem cells (ISCs) and subsequent return to quiescence. Here the authors show that return to quiescence by ISCs involves BMP Type I receptor Tkv protein stabilization along with AWD mediated internalization into endocytic vesicles.Xiaoyu Tracy CaiHongjie LiAbu SafyanJennifer GawlikGeorge PyrowolakisHeinrich JasperNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoyu Tracy Cai Hongjie Li Abu Safyan Jennifer Gawlik George Pyrowolakis Heinrich Jasper AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis
description	Regeneration after injury in the Drosophila intestine involves early activation of intestinal stem cells (ISCs) and subsequent return to quiescence. Here the authors show that return to quiescence by ISCs involves BMP Type I receptor Tkv protein stabilization along with AWD mediated internalization into endocytic vesicles.
format	article
author	Xiaoyu Tracy Cai Hongjie Li Abu Safyan Jennifer Gawlik George Pyrowolakis Heinrich Jasper
author_facet	Xiaoyu Tracy Cai Hongjie Li Abu Safyan Jennifer Gawlik George Pyrowolakis Heinrich Jasper
author_sort	Xiaoyu Tracy Cai
title	AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis
title_short	AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis
title_full	AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis
title_fullStr	AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis
title_full_unstemmed	AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis
title_sort	awd regulates timed activation of bmp signaling in intestinal stem cells to maintain tissue homeostasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/af7a2653f02440a7a060265fa985a893
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AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis

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