Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study

Abstract Background Depressive symptoms could be similarly expressed in bipolar and unipolar disorder. However, changes in cognition and brain networks might be quite distinct. We aimed to find out the difference in the neural mechanism of impaired working memory in patients with bipolar and unipola...

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Autores principales:	Zhinan Li, Junhao Chen, Yigang Feng, Shuming Zhong, Shui Tian, Zhongpeng Dai, Qing Lu, Yufang Guan, Yanyan Shan, Yanbin Jia
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Depression Working memory Frontoparietal network Magnetoencephalography Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/af7c7bc7e71445459c23333e3d70d156
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spelling	oai:doaj.org-article:af7c7bc7e71445459c23333e3d70d1562021-11-21T12:05:08ZDifferences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study10.1186/s12888-021-03595-31471-244Xhttps://doaj.org/article/af7c7bc7e71445459c23333e3d70d1562021-11-01T00:00:00Zhttps://doi.org/10.1186/s12888-021-03595-3https://doaj.org/toc/1471-244XAbstract Background Depressive symptoms could be similarly expressed in bipolar and unipolar disorder. However, changes in cognition and brain networks might be quite distinct. We aimed to find out the difference in the neural mechanism of impaired working memory in patients with bipolar and unipolar disorder. Method According to diagnostic criteria of bipolar II disorder of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and assessments, 13 bipolar II depression (BP II), 8 unipolar depression (UD) patients and 15 healthy controls (HC) were recruited in the study. We used 2-back tasks and magnetic source imaging (MSI) to test working memory functions and get the brain reactions of the participants. Results Compared with HC, only spatial working memory tasks accuracy was significantly worse in both UD and BP II (p = 0.001). Pearson correlation showed that the stronger the FCs’ strength of MFG-IPL and IPL-preSMA, the higher accuracy of SWM task within left FPN in patients with UD (r = 0.860, p = 0.006; r = 0.752, p = 0.031). However, the FC strength of IFG-IPL was negatively correlated with the accuracy of SWM task within left FPN in patients with BP II (r = − 0.591, p = 0.033). Conclusions Our study showed that the spatial working memory of patients with whether UD or BP II was impaired. The patterns of FCs within these two groups of patients were different when performing working memory tasks.Zhinan LiJunhao ChenYigang FengShuming ZhongShui TianZhongpeng DaiQing LuYufang GuanYanyan ShanYanbin JiaBMCarticleDepressionWorking memoryFrontoparietal networkMagnetoencephalographyPsychiatryRC435-571ENBMC Psychiatry, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Depression Working memory Frontoparietal network Magnetoencephalography Psychiatry RC435-571
spellingShingle	Depression Working memory Frontoparietal network Magnetoencephalography Psychiatry RC435-571 Zhinan Li Junhao Chen Yigang Feng Shuming Zhong Shui Tian Zhongpeng Dai Qing Lu Yufang Guan Yanyan Shan Yanbin Jia Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study
description	Abstract Background Depressive symptoms could be similarly expressed in bipolar and unipolar disorder. However, changes in cognition and brain networks might be quite distinct. We aimed to find out the difference in the neural mechanism of impaired working memory in patients with bipolar and unipolar disorder. Method According to diagnostic criteria of bipolar II disorder of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and assessments, 13 bipolar II depression (BP II), 8 unipolar depression (UD) patients and 15 healthy controls (HC) were recruited in the study. We used 2-back tasks and magnetic source imaging (MSI) to test working memory functions and get the brain reactions of the participants. Results Compared with HC, only spatial working memory tasks accuracy was significantly worse in both UD and BP II (p = 0.001). Pearson correlation showed that the stronger the FCs’ strength of MFG-IPL and IPL-preSMA, the higher accuracy of SWM task within left FPN in patients with UD (r = 0.860, p = 0.006; r = 0.752, p = 0.031). However, the FC strength of IFG-IPL was negatively correlated with the accuracy of SWM task within left FPN in patients with BP II (r = − 0.591, p = 0.033). Conclusions Our study showed that the spatial working memory of patients with whether UD or BP II was impaired. The patterns of FCs within these two groups of patients were different when performing working memory tasks.
format	article
author	Zhinan Li Junhao Chen Yigang Feng Shuming Zhong Shui Tian Zhongpeng Dai Qing Lu Yufang Guan Yanyan Shan Yanbin Jia
author_facet	Zhinan Li Junhao Chen Yigang Feng Shuming Zhong Shui Tian Zhongpeng Dai Qing Lu Yufang Guan Yanyan Shan Yanbin Jia
author_sort	Zhinan Li
title	Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study
title_short	Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study
title_full	Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study
title_fullStr	Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study
title_full_unstemmed	Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study
title_sort	differences in verbal and spatial working memory in patients with bipolar ii and unipolar depression: an msi study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/af7c7bc7e71445459c23333e3d70d156
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Differences in verbal and spatial working memory in patients with bipolar II and unipolar depression: an MSI study

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