TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

The tumour microenvironment is known to have an acidic pH but how this influences cancer cell phenotype is unclear. Here, the authors show that tumour cells upregulate TGF-β2 under acidosis, which leads to the increased formation of lipid droplets allowing for invasiveness and metastases.

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Autores principales:	Cyril Corbet, Estelle Bastien, Joao Pedro Santiago de Jesus, Emeline Dierge, Ruben Martherus, Catherine Vander Linden, Bastien Doix, Charline Degavre, Céline Guilbaud, Laurenne Petit, Carine Michiels, Chantal Dessy, Yvan Larondelle, Olivier Feron
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af7d4d7798c6436891d3d4c743591132
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spelling	oai:doaj.org-article:af7d4d7798c6436891d3d4c7435911322021-12-02T15:37:19ZTGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells10.1038/s41467-019-14262-32041-1723https://doaj.org/article/af7d4d7798c6436891d3d4c7435911322020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14262-3https://doaj.org/toc/2041-1723The tumour microenvironment is known to have an acidic pH but how this influences cancer cell phenotype is unclear. Here, the authors show that tumour cells upregulate TGF-β2 under acidosis, which leads to the increased formation of lipid droplets allowing for invasiveness and metastases.Cyril CorbetEstelle BastienJoao Pedro Santiago de JesusEmeline DiergeRuben MartherusCatherine Vander LindenBastien DoixCharline DegavreCéline GuilbaudLaurenne PetitCarine MichielsChantal DessyYvan LarondelleOlivier FeronNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cyril Corbet Estelle Bastien Joao Pedro Santiago de Jesus Emeline Dierge Ruben Martherus Catherine Vander Linden Bastien Doix Charline Degavre Céline Guilbaud Laurenne Petit Carine Michiels Chantal Dessy Yvan Larondelle Olivier Feron TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
description	The tumour microenvironment is known to have an acidic pH but how this influences cancer cell phenotype is unclear. Here, the authors show that tumour cells upregulate TGF-β2 under acidosis, which leads to the increased formation of lipid droplets allowing for invasiveness and metastases.
format	article
author	Cyril Corbet Estelle Bastien Joao Pedro Santiago de Jesus Emeline Dierge Ruben Martherus Catherine Vander Linden Bastien Doix Charline Degavre Céline Guilbaud Laurenne Petit Carine Michiels Chantal Dessy Yvan Larondelle Olivier Feron
author_facet	Cyril Corbet Estelle Bastien Joao Pedro Santiago de Jesus Emeline Dierge Ruben Martherus Catherine Vander Linden Bastien Doix Charline Degavre Céline Guilbaud Laurenne Petit Carine Michiels Chantal Dessy Yvan Larondelle Olivier Feron
author_sort	Cyril Corbet
title	TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
title_short	TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
title_full	TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
title_fullStr	TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
title_full_unstemmed	TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells
title_sort	tgfβ2-induced formation of lipid droplets supports acidosis-driven emt and the metastatic spreading of cancer cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/af7d4d7798c6436891d3d4c743591132
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TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

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