Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

Cardiovascular calcification is a serious pathology for which effective pharmacological treatments are lacking. Here the authors show that an optimized oligo(ethylene glycol) derivative of inositol phosphate interferes with calcium phosphate crystallization and inhibits soft tissue calcification in...

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Autores principales:	Antonia E. Schantl, Anja Verhulst, Ellen Neven, Geert J. Behets, Patrick C. D’Haese, Marc Maillard, David Mordasini, Olivier Phan, Michel Burnier, Dany Spaggiari, Laurent A. Decosterd, Mark G. MacAskill, Carlos J. Alcaide-Corral, Adriana A. S. Tavares, David E. Newby, Victoria C. Beindl, Roberto Maj, Anne Labarre, Chrismita Hegde, Bastien Castagner, Mattias E. Ivarsson, Jean-Christophe Leroux
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af7eef951f974f1d9573843564c6bad9
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spelling	oai:doaj.org-article:af7eef951f974f1d9573843564c6bad92021-12-02T14:41:04ZInhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers10.1038/s41467-019-14091-42041-1723https://doaj.org/article/af7eef951f974f1d9573843564c6bad92020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14091-4https://doaj.org/toc/2041-1723Cardiovascular calcification is a serious pathology for which effective pharmacological treatments are lacking. Here the authors show that an optimized oligo(ethylene glycol) derivative of inositol phosphate interferes with calcium phosphate crystallization and inhibits soft tissue calcification in vivo following subcutaneous injection.Antonia E. SchantlAnja VerhulstEllen NevenGeert J. BehetsPatrick C. D’HaeseMarc MaillardDavid MordasiniOlivier PhanMichel BurnierDany SpaggiariLaurent A. DecosterdMark G. MacAskillCarlos J. Alcaide-CorralAdriana A. S. TavaresDavid E. NewbyVictoria C. BeindlRoberto MajAnne LabarreChrismita HegdeBastien CastagnerMattias E. IvarssonJean-Christophe LerouxNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antonia E. Schantl Anja Verhulst Ellen Neven Geert J. Behets Patrick C. D’Haese Marc Maillard David Mordasini Olivier Phan Michel Burnier Dany Spaggiari Laurent A. Decosterd Mark G. MacAskill Carlos J. Alcaide-Corral Adriana A. S. Tavares David E. Newby Victoria C. Beindl Roberto Maj Anne Labarre Chrismita Hegde Bastien Castagner Mattias E. Ivarsson Jean-Christophe Leroux Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers
description	Cardiovascular calcification is a serious pathology for which effective pharmacological treatments are lacking. Here the authors show that an optimized oligo(ethylene glycol) derivative of inositol phosphate interferes with calcium phosphate crystallization and inhibits soft tissue calcification in vivo following subcutaneous injection.
format	article
author	Antonia E. Schantl Anja Verhulst Ellen Neven Geert J. Behets Patrick C. D’Haese Marc Maillard David Mordasini Olivier Phan Michel Burnier Dany Spaggiari Laurent A. Decosterd Mark G. MacAskill Carlos J. Alcaide-Corral Adriana A. S. Tavares David E. Newby Victoria C. Beindl Roberto Maj Anne Labarre Chrismita Hegde Bastien Castagner Mattias E. Ivarsson Jean-Christophe Leroux
author_facet	Antonia E. Schantl Anja Verhulst Ellen Neven Geert J. Behets Patrick C. D’Haese Marc Maillard David Mordasini Olivier Phan Michel Burnier Dany Spaggiari Laurent A. Decosterd Mark G. MacAskill Carlos J. Alcaide-Corral Adriana A. S. Tavares David E. Newby Victoria C. Beindl Roberto Maj Anne Labarre Chrismita Hegde Bastien Castagner Mattias E. Ivarsson Jean-Christophe Leroux
author_sort	Antonia E. Schantl
title	Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers
title_short	Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers
title_full	Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers
title_fullStr	Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers
title_full_unstemmed	Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers
title_sort	inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/af7eef951f974f1d9573843564c6bad9
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Inhibition of vascular calcification by inositol phosphates derivatized with ethylene glycol oligomers

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