Peptide-Based Drug Delivery Systems

Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and purification. Lysosomes, solid lipid nanoparticle...

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Autores principales:	Dmitriy Berillo, Adilkhan Yeskendir, Zharylkasyn Zharkinbekov, Kamila Raziyeva, Arman Saparov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	drug delivery system drug carriers peptide-based cell penetrating peptides targeted delivery stimuli responsive Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/af81c5ef985d490088352b40b753c194
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spelling	oai:doaj.org-article:af81c5ef985d490088352b40b753c1942021-11-25T18:18:35ZPeptide-Based Drug Delivery Systems10.3390/medicina571112091648-91441010-660Xhttps://doaj.org/article/af81c5ef985d490088352b40b753c1942021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1209https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and purification. Lysosomes, solid lipid nanoparticles, dendrimers, polymeric micelles can be applied by intravenous administration, however they are of artificial nature and thus may induce side effects and possess lack of ability to penetrate the blood-brain barrier. An analysis of nontoxic drug delivery systems and an establishment of prospective trends in the development of drug delivery systems was needed. This review paper summarizes data, mainly from the past 5 years, devoted to the use of peptide-based carriers for delivery of various toxic drugs, mostly anticancer or drugs with limiting bioavailability. Peptide-based drug delivery platforms are utilized as peptide–drug conjugates, injectable biodegradable particles and depots for delivering small molecule pharmaceutical substances (500 Da) and therapeutic proteins. Controlled drug delivery systems that can effectively deliver anticancer and peptide-based drugs leading to accelerated recovery without significant side effects are discussed. Moreover, cell penetrating peptides and their molecular mechanisms as targeting peptides, as well as stimuli responsive (enzyme-responsive and pH-responsive) peptides and peptide-based self-assembly scaffolds are also reviewed.Dmitriy BerilloAdilkhan YeskendirZharylkasyn ZharkinbekovKamila RaziyevaArman SaparovMDPI AGarticledrug delivery systemdrug carrierspeptide-basedcell penetrating peptidestargeted deliverystimuli responsiveMedicine (General)R5-920ENMedicina, Vol 57, Iss 1209, p 1209 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug delivery system drug carriers peptide-based cell penetrating peptides targeted delivery stimuli responsive Medicine (General) R5-920
spellingShingle	drug delivery system drug carriers peptide-based cell penetrating peptides targeted delivery stimuli responsive Medicine (General) R5-920 Dmitriy Berillo Adilkhan Yeskendir Zharylkasyn Zharkinbekov Kamila Raziyeva Arman Saparov Peptide-Based Drug Delivery Systems
description	Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and purification. Lysosomes, solid lipid nanoparticles, dendrimers, polymeric micelles can be applied by intravenous administration, however they are of artificial nature and thus may induce side effects and possess lack of ability to penetrate the blood-brain barrier. An analysis of nontoxic drug delivery systems and an establishment of prospective trends in the development of drug delivery systems was needed. This review paper summarizes data, mainly from the past 5 years, devoted to the use of peptide-based carriers for delivery of various toxic drugs, mostly anticancer or drugs with limiting bioavailability. Peptide-based drug delivery platforms are utilized as peptide–drug conjugates, injectable biodegradable particles and depots for delivering small molecule pharmaceutical substances (500 Da) and therapeutic proteins. Controlled drug delivery systems that can effectively deliver anticancer and peptide-based drugs leading to accelerated recovery without significant side effects are discussed. Moreover, cell penetrating peptides and their molecular mechanisms as targeting peptides, as well as stimuli responsive (enzyme-responsive and pH-responsive) peptides and peptide-based self-assembly scaffolds are also reviewed.
format	article
author	Dmitriy Berillo Adilkhan Yeskendir Zharylkasyn Zharkinbekov Kamila Raziyeva Arman Saparov
author_facet	Dmitriy Berillo Adilkhan Yeskendir Zharylkasyn Zharkinbekov Kamila Raziyeva Arman Saparov
author_sort	Dmitriy Berillo
title	Peptide-Based Drug Delivery Systems
title_short	Peptide-Based Drug Delivery Systems
title_full	Peptide-Based Drug Delivery Systems
title_fullStr	Peptide-Based Drug Delivery Systems
title_full_unstemmed	Peptide-Based Drug Delivery Systems
title_sort	peptide-based drug delivery systems
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/af81c5ef985d490088352b40b753c194
work_keys_str_mv	AT dmitriyberillo peptidebaseddrugdeliverysystems AT adilkhanyeskendir peptidebaseddrugdeliverysystems AT zharylkasynzharkinbekov peptidebaseddrugdeliverysystems AT kamilaraziyeva peptidebaseddrugdeliverysystems AT armansaparov peptidebaseddrugdeliverysystems
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Peptide-Based Drug Delivery Systems

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