RING tetramerization is required for nuclear body biogenesis and PML sumoylation

Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear body formation and PML sumoylation.

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Autores principales:	Pengran Wang, Shirine Benhenda, Haiyan Wu, Valérie Lallemand-Breitenbach, Tao Zhen, Florence Jollivet, Laurent Peres, Yuwen Li, Sai-Juan Chen, Zhu Chen, Hugues de Thé, Guoyu Meng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af84ac66c1354f56901c8f3934d5f6be
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spelling	oai:doaj.org-article:af84ac66c1354f56901c8f3934d5f6be2021-12-02T17:31:27ZRING tetramerization is required for nuclear body biogenesis and PML sumoylation10.1038/s41467-018-03498-02041-1723https://doaj.org/article/af84ac66c1354f56901c8f3934d5f6be2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03498-0https://doaj.org/toc/2041-1723Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear body formation and PML sumoylation.Pengran WangShirine BenhendaHaiyan WuValérie Lallemand-BreitenbachTao ZhenFlorence JollivetLaurent PeresYuwen LiSai-Juan ChenZhu ChenHugues de ThéGuoyu MengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pengran Wang Shirine Benhenda Haiyan Wu Valérie Lallemand-Breitenbach Tao Zhen Florence Jollivet Laurent Peres Yuwen Li Sai-Juan Chen Zhu Chen Hugues de Thé Guoyu Meng RING tetramerization is required for nuclear body biogenesis and PML sumoylation
description	Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear body formation and PML sumoylation.
format	article
author	Pengran Wang Shirine Benhenda Haiyan Wu Valérie Lallemand-Breitenbach Tao Zhen Florence Jollivet Laurent Peres Yuwen Li Sai-Juan Chen Zhu Chen Hugues de Thé Guoyu Meng
author_facet	Pengran Wang Shirine Benhenda Haiyan Wu Valérie Lallemand-Breitenbach Tao Zhen Florence Jollivet Laurent Peres Yuwen Li Sai-Juan Chen Zhu Chen Hugues de Thé Guoyu Meng
author_sort	Pengran Wang
title	RING tetramerization is required for nuclear body biogenesis and PML sumoylation
title_short	RING tetramerization is required for nuclear body biogenesis and PML sumoylation
title_full	RING tetramerization is required for nuclear body biogenesis and PML sumoylation
title_fullStr	RING tetramerization is required for nuclear body biogenesis and PML sumoylation
title_full_unstemmed	RING tetramerization is required for nuclear body biogenesis and PML sumoylation
title_sort	ring tetramerization is required for nuclear body biogenesis and pml sumoylation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/af84ac66c1354f56901c8f3934d5f6be
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_version_	1718380632523931648

RING tetramerization is required for nuclear body biogenesis and PML sumoylation

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