RING tetramerization is required for nuclear body biogenesis and PML sumoylation
Promyelocytic leukemia protein (PML) is a scaffolding protein that organizes PML nuclear bodies. Here the authors present the tetrameric crystal structure of the PML RING domain and show that RING tetramerization is functionally important for nuclear body formation and PML sumoylation.
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Auteurs principaux: | Pengran Wang, Shirine Benhenda, Haiyan Wu, Valérie Lallemand-Breitenbach, Tao Zhen, Florence Jollivet, Laurent Peres, Yuwen Li, Sai-Juan Chen, Zhu Chen, Hugues de Thé, Guoyu Meng |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
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Accès en ligne: | https://doaj.org/article/af84ac66c1354f56901c8f3934d5f6be |
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