Vitreous levels of vascular endothelial growth factor in eyes with anterior hyaloidal fibrovascular proliferation

Takaki Kobayashi, Shigeki Machida, Takamitsu Fujiwara, Tadashi Ishibe, Daijiro KurosakaDepartment of Ophthalmology, Iwate Medical University School of Medicine, Iwate, JapanPurpose: To determine the intravitreal levels of vascular endothelial growth factor (VEGF) in eyes with anterior hyaloidal fibr...

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Autores principales: Takaki Kobayashi, Shigeki Machida, Takamitsu Fujiwara, et al
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Publicado: Dove Medical Press 2010
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spelling oai:doaj.org-article:af84f8cee9134ce98486586f26d71df22021-12-02T00:13:27ZVitreous levels of vascular endothelial growth factor in eyes with anterior hyaloidal fibrovascular proliferation1177-54671177-5483https://doaj.org/article/af84f8cee9134ce98486586f26d71df22010-09-01T00:00:00Zhttp://www.dovepress.com/vitreous-levels-of-vascular-endothelial-growth-factor-in-eyes-with-ant-a5309https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Takaki Kobayashi, Shigeki Machida, Takamitsu Fujiwara, Tadashi Ishibe, Daijiro KurosakaDepartment of Ophthalmology, Iwate Medical University School of Medicine, Iwate, JapanPurpose: To determine the intravitreal levels of vascular endothelial growth factor (VEGF) in eyes with anterior hyaloidal fibrovascular proliferation (AHFVP).Methods: Three eyes of three patients who underwent vitrectomy for proliferative diabetic retinopathy (PDR) and subsequently developed an AHFVP (AHFVP group) were studied. We measured the level of VEGF in vitreous samples collected at the primary and following operations by enzyme-linked immunosorbent assay. The vitreous levels of VEGF in 25 eyes of 22 patients with PDR were also studied as controls (PDR group).Results: The averaged VEGF level in the samples collected at the primary surgery was 1.98 ± 2.23 ng/mL in the PDR group, and it was 9.07, 1.94, and 8.07 ng/mL in the AHFVP cases. After the primary surgery, the VEGF level rose up to 49.50, 15.60, and 50.60 ng/mL at the subsequent surgeries for respective cases of the AHFVP group. These levels of VEGF were more than five times higher than the baseline at the primary surgery.Conclusion: The subsequent increase of the VEGF level after the primary surgery in eyes with an AHFVP suggests that the vitreous levels of VEGF are associated with the development of the AHFVP although only three eyes were studied.Keywords: VEGF, AHFVP, diabetic retinopathy Takaki KobayashiShigeki MachidaTakamitsu Fujiwaraet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 1043-1046 (2010)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Takaki Kobayashi
Shigeki Machida
Takamitsu Fujiwara
et al
Vitreous levels of vascular endothelial growth factor in eyes with anterior hyaloidal fibrovascular proliferation
description Takaki Kobayashi, Shigeki Machida, Takamitsu Fujiwara, Tadashi Ishibe, Daijiro KurosakaDepartment of Ophthalmology, Iwate Medical University School of Medicine, Iwate, JapanPurpose: To determine the intravitreal levels of vascular endothelial growth factor (VEGF) in eyes with anterior hyaloidal fibrovascular proliferation (AHFVP).Methods: Three eyes of three patients who underwent vitrectomy for proliferative diabetic retinopathy (PDR) and subsequently developed an AHFVP (AHFVP group) were studied. We measured the level of VEGF in vitreous samples collected at the primary and following operations by enzyme-linked immunosorbent assay. The vitreous levels of VEGF in 25 eyes of 22 patients with PDR were also studied as controls (PDR group).Results: The averaged VEGF level in the samples collected at the primary surgery was 1.98 ± 2.23 ng/mL in the PDR group, and it was 9.07, 1.94, and 8.07 ng/mL in the AHFVP cases. After the primary surgery, the VEGF level rose up to 49.50, 15.60, and 50.60 ng/mL at the subsequent surgeries for respective cases of the AHFVP group. These levels of VEGF were more than five times higher than the baseline at the primary surgery.Conclusion: The subsequent increase of the VEGF level after the primary surgery in eyes with an AHFVP suggests that the vitreous levels of VEGF are associated with the development of the AHFVP although only three eyes were studied.Keywords: VEGF, AHFVP, diabetic retinopathy
format article
author Takaki Kobayashi
Shigeki Machida
Takamitsu Fujiwara
et al
author_facet Takaki Kobayashi
Shigeki Machida
Takamitsu Fujiwara
et al
author_sort Takaki Kobayashi
title Vitreous levels of vascular endothelial growth factor in eyes with anterior hyaloidal fibrovascular proliferation
title_short Vitreous levels of vascular endothelial growth factor in eyes with anterior hyaloidal fibrovascular proliferation
title_full Vitreous levels of vascular endothelial growth factor in eyes with anterior hyaloidal fibrovascular proliferation
title_fullStr Vitreous levels of vascular endothelial growth factor in eyes with anterior hyaloidal fibrovascular proliferation
title_full_unstemmed Vitreous levels of vascular endothelial growth factor in eyes with anterior hyaloidal fibrovascular proliferation
title_sort vitreous levels of vascular endothelial growth factor in eyes with anterior hyaloidal fibrovascular proliferation
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/af84f8cee9134ce98486586f26d71df2
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