Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19

Deficiencies in smell and taste are common symptoms of COVID-19. Quantitative losses are well surveyed. This study focuses on qualitative changes such as phantosmia (hallucination of smell), parosmia (alteration of smell), and dysgeusia (alteration of taste) and possible connections with the adaptiv...

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Autores principales:	Sophia E. Schambeck, Claudia S. Crowell, Karolin I. Wagner, Elvira D’Ippolito, Teresa Burrell, Hrvoje Mijočević, Ulrike Protzer, Dirk H. Busch, Markus Gerhard, Holger Poppert, Henriette Beyer
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	parosmia phantosmia dysgeusia smell taste coronavirus Medicine R
Acceso en línea:	https://doaj.org/article/af8753a1b4f445ae86cb991e7f076f8e
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spelling	oai:doaj.org-article:af8753a1b4f445ae86cb991e7f076f8e2021-11-25T18:01:07ZPhantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-1910.3390/jcm102252662077-0383https://doaj.org/article/af8753a1b4f445ae86cb991e7f076f8e2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5266https://doaj.org/toc/2077-0383Deficiencies in smell and taste are common symptoms of COVID-19. Quantitative losses are well surveyed. This study focuses on qualitative changes such as phantosmia (hallucination of smell), parosmia (alteration of smell), and dysgeusia (alteration of taste) and possible connections with the adaptive immune system. Subjective experience of deficiency in taste and smell was assessed by two different questionnaires after a median of 100 and 244 days after first positive RT-PCR test. SARS-CoV-2-specific antibody levels were measured with the iFlash-SARS-CoV-2 assay. After 100 days a psychophysical screening test for olfactory and gustatory dysfunction was administered. 30 of 44 (68.2%) participants reported a chemosensory dysfunction (14 quantitative, 6 qualitative, 10 quantitative, and qualitative) during COVID-19, eleven (25.0%) participants (1 quantitative, 7 qualitative, 3 quantitative, and quantity) after 100 days, and 14 (31.8%) participants (1 quantitative, 10 qualitative, 3 quantitative and qualitative) after 244 days. Four (9.1%) participants, who were symptom-free after 100 days reported now recently arisen qualitative changes. Serological and T-cell analysis showed no correlation with impairment of taste and smell. In conclusion, qualitative changes can persist for several months and occur as late-onset symptoms months after full recovery from COVID-19-induced quantitative losses in taste and smell.Sophia E. SchambeckClaudia S. CrowellKarolin I. WagnerElvira D’IppolitoTeresa BurrellHrvoje MijočevićUlrike ProtzerDirk H. BuschMarkus GerhardHolger PoppertHenriette BeyerMDPI AGarticleparosmiaphantosmiadysgeusiasmelltastecoronavirusMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5266, p 5266 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	parosmia phantosmia dysgeusia smell taste coronavirus Medicine R
spellingShingle	parosmia phantosmia dysgeusia smell taste coronavirus Medicine R Sophia E. Schambeck Claudia S. Crowell Karolin I. Wagner Elvira D’Ippolito Teresa Burrell Hrvoje Mijočević Ulrike Protzer Dirk H. Busch Markus Gerhard Holger Poppert Henriette Beyer Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
description	Deficiencies in smell and taste are common symptoms of COVID-19. Quantitative losses are well surveyed. This study focuses on qualitative changes such as phantosmia (hallucination of smell), parosmia (alteration of smell), and dysgeusia (alteration of taste) and possible connections with the adaptive immune system. Subjective experience of deficiency in taste and smell was assessed by two different questionnaires after a median of 100 and 244 days after first positive RT-PCR test. SARS-CoV-2-specific antibody levels were measured with the iFlash-SARS-CoV-2 assay. After 100 days a psychophysical screening test for olfactory and gustatory dysfunction was administered. 30 of 44 (68.2%) participants reported a chemosensory dysfunction (14 quantitative, 6 qualitative, 10 quantitative, and qualitative) during COVID-19, eleven (25.0%) participants (1 quantitative, 7 qualitative, 3 quantitative, and quantity) after 100 days, and 14 (31.8%) participants (1 quantitative, 10 qualitative, 3 quantitative and qualitative) after 244 days. Four (9.1%) participants, who were symptom-free after 100 days reported now recently arisen qualitative changes. Serological and T-cell analysis showed no correlation with impairment of taste and smell. In conclusion, qualitative changes can persist for several months and occur as late-onset symptoms months after full recovery from COVID-19-induced quantitative losses in taste and smell.
format	article
author	Sophia E. Schambeck Claudia S. Crowell Karolin I. Wagner Elvira D’Ippolito Teresa Burrell Hrvoje Mijočević Ulrike Protzer Dirk H. Busch Markus Gerhard Holger Poppert Henriette Beyer
author_facet	Sophia E. Schambeck Claudia S. Crowell Karolin I. Wagner Elvira D’Ippolito Teresa Burrell Hrvoje Mijočević Ulrike Protzer Dirk H. Busch Markus Gerhard Holger Poppert Henriette Beyer
author_sort	Sophia E. Schambeck
title	Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
title_short	Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
title_full	Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
title_fullStr	Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
title_full_unstemmed	Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19
title_sort	phantosmia, parosmia, and dysgeusia are prolonged and late-onset symptoms of covid-19
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/af8753a1b4f445ae86cb991e7f076f8e
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Phantosmia, Parosmia, and Dysgeusia Are Prolonged and Late-Onset Symptoms of COVID-19

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