Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China.

A key observation about the human immune response to repeated exposure to influenza A is that the first strain infecting an individual apparently produces the strongest adaptive immune response. Although antibody titers measure that response, the interpretation of titers to multiple strains--from th...

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Autores principales:	Justin Lessler, Steven Riley, Jonathan M Read, Shuying Wang, Huachen Zhu, Gavin J D Smith, Yi Guan, Chao Qiang Jiang, Derek A T Cummings
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/af8f3ae9e90141c3825ac5cd46d4e917
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spelling	oai:doaj.org-article:af8f3ae9e90141c3825ac5cd46d4e9172021-11-18T06:04:12ZEvidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China.1553-73661553-737410.1371/journal.ppat.1002802https://doaj.org/article/af8f3ae9e90141c3825ac5cd46d4e9172012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22829765/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374A key observation about the human immune response to repeated exposure to influenza A is that the first strain infecting an individual apparently produces the strongest adaptive immune response. Although antibody titers measure that response, the interpretation of titers to multiple strains--from the same sera--in terms of infection history is clouded by age effects, cross reactivity and immune waning. From July to September 2009, we collected serum samples from 151 residents of Guangdong Province, China, 7 to 81 years of age. Neutralization tests were performed against strains representing six antigenic clusters of H3N2 influenza circulating between 1968 and 2008, and three recent locally circulating strains. Patterns of neutralization titers were compared based on age at time of testing and age at time of the first isolation of each virus. Neutralization titers were highest for H3N2 strains that circulated in an individual's first decade of life (peaking at 7 years). Further, across strains and ages at testing, statistical models strongly supported a pattern of titers declining smoothly with age at the time a strain was first isolated. Those born 10 or more years after a strain emerged generally had undetectable neutralization titers to that strain (<1:10). Among those over 60 at time of testing, titers tended to increase with age. The observed pattern in H3N2 neutralization titers can be characterized as one of antigenic seniority: repeated exposure and the immune response combine to produce antibody titers that are higher to more 'senior' strains encountered earlier in life.Justin LesslerSteven RileyJonathan M ReadShuying WangHuachen ZhuGavin J D SmithYi GuanChao Qiang JiangDerek A T CummingsPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 8, Iss 7, p e1002802 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Justin Lessler Steven Riley Jonathan M Read Shuying Wang Huachen Zhu Gavin J D Smith Yi Guan Chao Qiang Jiang Derek A T Cummings Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China.
description	A key observation about the human immune response to repeated exposure to influenza A is that the first strain infecting an individual apparently produces the strongest adaptive immune response. Although antibody titers measure that response, the interpretation of titers to multiple strains--from the same sera--in terms of infection history is clouded by age effects, cross reactivity and immune waning. From July to September 2009, we collected serum samples from 151 residents of Guangdong Province, China, 7 to 81 years of age. Neutralization tests were performed against strains representing six antigenic clusters of H3N2 influenza circulating between 1968 and 2008, and three recent locally circulating strains. Patterns of neutralization titers were compared based on age at time of testing and age at time of the first isolation of each virus. Neutralization titers were highest for H3N2 strains that circulated in an individual's first decade of life (peaking at 7 years). Further, across strains and ages at testing, statistical models strongly supported a pattern of titers declining smoothly with age at the time a strain was first isolated. Those born 10 or more years after a strain emerged generally had undetectable neutralization titers to that strain (<1:10). Among those over 60 at time of testing, titers tended to increase with age. The observed pattern in H3N2 neutralization titers can be characterized as one of antigenic seniority: repeated exposure and the immune response combine to produce antibody titers that are higher to more 'senior' strains encountered earlier in life.
format	article
author	Justin Lessler Steven Riley Jonathan M Read Shuying Wang Huachen Zhu Gavin J D Smith Yi Guan Chao Qiang Jiang Derek A T Cummings
author_facet	Justin Lessler Steven Riley Jonathan M Read Shuying Wang Huachen Zhu Gavin J D Smith Yi Guan Chao Qiang Jiang Derek A T Cummings
author_sort	Justin Lessler
title	Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China.
title_short	Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China.
title_full	Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China.
title_fullStr	Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China.
title_full_unstemmed	Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China.
title_sort	evidence for antigenic seniority in influenza a (h3n2) antibody responses in southern china.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/af8f3ae9e90141c3825ac5cd46d4e917
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Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China.

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