Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a heterogeneous disease, causing severe breathing problems and cardiac morbidity. Here, the authors study chromatin marks in pulmonary arterial endothelial cells from PAH patients and controls and find changes in transcription factor and enhancer activity tha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Armando Reyes-Palomares, Mingxia Gu, Fabian Grubert, Ivan Berest, Silin Sa, Maya Kasowski, Christian Arnold, Mao Shuai, Rohith Srivas, Simon Miao, Dan Li, Michael P. Snyder, Marlene Rabinovitch, Judith B. Zaugg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af8f51e6fdcf4006aee980f4873bd8eb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:af8f51e6fdcf4006aee980f4873bd8eb
record_format	dspace
spelling	oai:doaj.org-article:af8f51e6fdcf4006aee980f4873bd8eb2021-12-02T17:32:27ZRemodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension10.1038/s41467-020-15463-x2041-1723https://doaj.org/article/af8f51e6fdcf4006aee980f4873bd8eb2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15463-xhttps://doaj.org/toc/2041-1723Pulmonary arterial hypertension (PAH) is a heterogeneous disease, causing severe breathing problems and cardiac morbidity. Here, the authors study chromatin marks in pulmonary arterial endothelial cells from PAH patients and controls and find changes in transcription factor and enhancer activity that suggest an aberrant response to signalling in PAH.Armando Reyes-PalomaresMingxia GuFabian GrubertIvan BerestSilin SaMaya KasowskiChristian ArnoldMao ShuaiRohith SrivasSimon MiaoDan LiMichael P. SnyderMarlene RabinovitchJudith B. ZauggNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Armando Reyes-Palomares Mingxia Gu Fabian Grubert Ivan Berest Silin Sa Maya Kasowski Christian Arnold Mao Shuai Rohith Srivas Simon Miao Dan Li Michael P. Snyder Marlene Rabinovitch Judith B. Zaugg Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension
description	Pulmonary arterial hypertension (PAH) is a heterogeneous disease, causing severe breathing problems and cardiac morbidity. Here, the authors study chromatin marks in pulmonary arterial endothelial cells from PAH patients and controls and find changes in transcription factor and enhancer activity that suggest an aberrant response to signalling in PAH.
format	article
author	Armando Reyes-Palomares Mingxia Gu Fabian Grubert Ivan Berest Silin Sa Maya Kasowski Christian Arnold Mao Shuai Rohith Srivas Simon Miao Dan Li Michael P. Snyder Marlene Rabinovitch Judith B. Zaugg
author_facet	Armando Reyes-Palomares Mingxia Gu Fabian Grubert Ivan Berest Silin Sa Maya Kasowski Christian Arnold Mao Shuai Rohith Srivas Simon Miao Dan Li Michael P. Snyder Marlene Rabinovitch Judith B. Zaugg
author_sort	Armando Reyes-Palomares
title	Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension
title_short	Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension
title_full	Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension
title_fullStr	Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension
title_full_unstemmed	Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension
title_sort	remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/af8f51e6fdcf4006aee980f4873bd8eb
work_keys_str_mv	AT armandoreyespalomares remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT mingxiagu remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT fabiangrubert remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT ivanberest remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT silinsa remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT mayakasowski remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT christianarnold remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT maoshuai remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT rohithsrivas remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT simonmiao remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT danli remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT michaelpsnyder remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT marlenerabinovitch remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension AT judithbzaugg remodelingofactiveendothelialenhancersisassociatedwithaberrantgeneregulatorynetworksinpulmonaryarterialhypertension
_version_	1718380328215642112

Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension

Ejemplares similares