Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy

Chemotherapy is a traditional treatment method in clinical cancer treatment. However, it is limited due to the large toxic side effects of chemotherapeutics. Nanomedicines have shown great potential in the application of tumor therapy. The size of nanoparticles as a crucial factor in the enhanced pe...

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Autores principales:	Meng Gao, Yue Chen, Chenghu Wu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	malignant glioma doxorubicin-loaded nanoparticles chemosensitization tumor chemotherapy size-dependent Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/af8fcf5186df4ec9b64cc06e102ff80d
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spelling	oai:doaj.org-article:af8fcf5186df4ec9b64cc06e102ff80d2021-11-17T14:21:59ZSize-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy2165-59792165-598710.1080/21655979.2021.2006568https://doaj.org/article/af8fcf5186df4ec9b64cc06e102ff80d2021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2006568https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Chemotherapy is a traditional treatment method in clinical cancer treatment. However, it is limited due to the large toxic side effects of chemotherapeutics. Nanomedicines have shown great potential in the application of tumor therapy. The size of nanoparticles as a crucial factor in the enhanced permeability and retention (EPR) effect can be regulated for the enhanced chemotherapy. Therefore, we believe that regulation of nanoparticle size can be used as an effective sensitizer to enhance the therapeutic effect of chemotherapy drugs on tumors. Here, we prepared several nanoparticles of different hydrodynamic diameters commonly found in nanomedical applications by the diblock copolymer of methoxy polyethylene glycol- poly (ϵ‐caprolactone) (mPEG-PCL). The blood circulation effect and organ distribution in blood were detected by fluorescence labeled nanoparticles. We found that the small-sized nanoparticles exhibited much longer blood circulation time than the large-sized nanoparticles in vivo, and thus the nanoparticle concentration in the tumor tissue was relatively high. Systematic injection of the doxorubicin (DOX) loaded nanoparticles can effectively inhibit tumor growth. Compared to the free drug, tumor cells were much more sensitive to DOX loaded nanoparticles of small size. Our nano-drug delivery system has been proven to be safe and non-toxic in vivo and was suitable for use as a sensitizer in clinical oncology chemotherapy.Meng GaoYue ChenChenghu WuTaylor & Francis Grouparticlemalignant gliomadoxorubicin-loaded nanoparticleschemosensitizationtumor chemotherapysize-dependentBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	malignant glioma doxorubicin-loaded nanoparticles chemosensitization tumor chemotherapy size-dependent Biotechnology TP248.13-248.65
spellingShingle	malignant glioma doxorubicin-loaded nanoparticles chemosensitization tumor chemotherapy size-dependent Biotechnology TP248.13-248.65 Meng Gao Yue Chen Chenghu Wu Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy
description	Chemotherapy is a traditional treatment method in clinical cancer treatment. However, it is limited due to the large toxic side effects of chemotherapeutics. Nanomedicines have shown great potential in the application of tumor therapy. The size of nanoparticles as a crucial factor in the enhanced permeability and retention (EPR) effect can be regulated for the enhanced chemotherapy. Therefore, we believe that regulation of nanoparticle size can be used as an effective sensitizer to enhance the therapeutic effect of chemotherapy drugs on tumors. Here, we prepared several nanoparticles of different hydrodynamic diameters commonly found in nanomedical applications by the diblock copolymer of methoxy polyethylene glycol- poly (ϵ‐caprolactone) (mPEG-PCL). The blood circulation effect and organ distribution in blood were detected by fluorescence labeled nanoparticles. We found that the small-sized nanoparticles exhibited much longer blood circulation time than the large-sized nanoparticles in vivo, and thus the nanoparticle concentration in the tumor tissue was relatively high. Systematic injection of the doxorubicin (DOX) loaded nanoparticles can effectively inhibit tumor growth. Compared to the free drug, tumor cells were much more sensitive to DOX loaded nanoparticles of small size. Our nano-drug delivery system has been proven to be safe and non-toxic in vivo and was suitable for use as a sensitizer in clinical oncology chemotherapy.
format	article
author	Meng Gao Yue Chen Chenghu Wu
author_facet	Meng Gao Yue Chen Chenghu Wu
author_sort	Meng Gao
title	Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy
title_short	Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy
title_full	Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy
title_fullStr	Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy
title_full_unstemmed	Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy
title_sort	size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/af8fcf5186df4ec9b64cc06e102ff80d
work_keys_str_mv	AT menggao sizedependentchemosensitizationofdoxorubicinloadedpolymericnanoparticlesformalignantgliomachemotherapy AT yuechen sizedependentchemosensitizationofdoxorubicinloadedpolymericnanoparticlesformalignantgliomachemotherapy AT chenghuwu sizedependentchemosensitizationofdoxorubicinloadedpolymericnanoparticlesformalignantgliomachemotherapy
_version_	1718425437019832320

Size-dependent chemosensitization of doxorubicin-loaded polymeric nanoparticles for malignant glioma chemotherapy

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