Aging and extrapulmonary effects of chronic obstructive pulmonary disease

Emanuela Tudorache,1 Ariadna Petronela Fildan,2 Mirela Frandes,3 Elena Dantes,4 Doina Ecaterina Tofolean2 1Department of Pulmonology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara, 2Faculty of Medicine, Internal Medicine Discipline, Medical Clinical Disciplines I...

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Autores principales:	Tudorache E, Fildan AP, Frandes M, Dantes E, Tofolean DE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	ageing inflammation strength pulmonary function Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/af9211ffdf384092ad781d7185246b4c
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spelling	oai:doaj.org-article:af9211ffdf384092ad781d7185246b4c2021-12-02T02:40:06ZAging and extrapulmonary effects of chronic obstructive pulmonary disease1178-1998https://doaj.org/article/af9211ffdf384092ad781d7185246b4c2017-08-01T00:00:00Zhttps://www.dovepress.com/aging-and-extrapulmonary-effects-of-chronic-obstructive-pulmonary-dise-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Emanuela Tudorache,1 Ariadna Petronela Fildan,2 Mirela Frandes,3 Elena Dantes,4 Doina Ecaterina Tofolean2 1Department of Pulmonology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara, 2Faculty of Medicine, Internal Medicine Discipline, Medical Clinical Disciplines I, “Ovidius” University of Constanta, Constanţa, 3Department of Functional Sciences, “Victor Babes” University of Medicine and Pharmacy, Timişoara, 4Faculty of Medicine, Pneumophtisiology Department, Medical Clinical Disciplines II, “Ovidius” University Constanta, Constanţa, Romania Introduction: People with COPD have a decline in functional status, but little is known about the rate of decline and factors that contribute. Of particular concern is the decline in cognitive and functional performance. Decrease in cognitive and functional performance will finally lead to decreased health status, sedentary life style and premature frailty. Aim: The aim of this study is to compare functional performance and cognitive status in patients with COPD of different ages and to examine the changes in extrapulmonary effects. Patients and methods: This study included 62 patients with COPD risk class D who were divided into two groups (<70 years, N=30 and >70 years, N=32). Patients first completed the Montreal Cognitive Assessment (MoCA), which is a 30-point test that assesses different cognitive domains, while isometric knee extension (IKE) was measured using a digital handheld dynamometer, and functional exercise level was assessed using the 6-minute walking distance (6MWD) test. Results: The patients’ older age (age higher than 70 years) was associated with a significantly lower body mass index (BMI, 27.50 vs 24.24 kg/m2; P=0.020), higher vital capacity parameters, forced vital capacity (FVC, 2.74 vs 2.82 L; P=0.799), FVC (%) (73.00 vs 66.50, P=132), forced expiratory volume in the first second (FEV1, 0.93 vs 1.13 L; P=0.001) and FEV1 (%) (28.50 vs 30.50, P=0.605). In addition, patients at older age presented a significantly reduced physical activity capacity, 6MWD (385.93 vs 320.84 m, P<0.001) and IKE (24.75 vs 22.55 kgf, P=0.005), as well as higher values for inflammatory biomarkers, C-reactive protein (8.77 vs 3.34 mg/L, P=0.022). Moreover, patients at older age presented significantly lower score at the cognitive assessment, MoCA (23.50 vs 20.00, P<0.001). Conclusion: Elderly COPD patients have reduced exercise capacity and muscle strength, deteriorated cognitive function and increased inflammatory markers. Furthermore, inflammation markers were significantly correlated with muscle strength, walking distance and cognitive impairment. Keywords: aging, inflammation, strength, pulmonary functionTudorache EFildan APFrandes MDantes ETofolean DEDove Medical Pressarticleageinginflammationstrengthpulmonary functionGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 1281-1287 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	ageing inflammation strength pulmonary function Geriatrics RC952-954.6
spellingShingle	ageing inflammation strength pulmonary function Geriatrics RC952-954.6 Tudorache E Fildan AP Frandes M Dantes E Tofolean DE Aging and extrapulmonary effects of chronic obstructive pulmonary disease
description	Emanuela Tudorache,1 Ariadna Petronela Fildan,2 Mirela Frandes,3 Elena Dantes,4 Doina Ecaterina Tofolean2 1Department of Pulmonology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara, 2Faculty of Medicine, Internal Medicine Discipline, Medical Clinical Disciplines I, “Ovidius” University of Constanta, Constanţa, 3Department of Functional Sciences, “Victor Babes” University of Medicine and Pharmacy, Timişoara, 4Faculty of Medicine, Pneumophtisiology Department, Medical Clinical Disciplines II, “Ovidius” University Constanta, Constanţa, Romania Introduction: People with COPD have a decline in functional status, but little is known about the rate of decline and factors that contribute. Of particular concern is the decline in cognitive and functional performance. Decrease in cognitive and functional performance will finally lead to decreased health status, sedentary life style and premature frailty. Aim: The aim of this study is to compare functional performance and cognitive status in patients with COPD of different ages and to examine the changes in extrapulmonary effects. Patients and methods: This study included 62 patients with COPD risk class D who were divided into two groups (<70 years, N=30 and >70 years, N=32). Patients first completed the Montreal Cognitive Assessment (MoCA), which is a 30-point test that assesses different cognitive domains, while isometric knee extension (IKE) was measured using a digital handheld dynamometer, and functional exercise level was assessed using the 6-minute walking distance (6MWD) test. Results: The patients’ older age (age higher than 70 years) was associated with a significantly lower body mass index (BMI, 27.50 vs 24.24 kg/m2; P=0.020), higher vital capacity parameters, forced vital capacity (FVC, 2.74 vs 2.82 L; P=0.799), FVC (%) (73.00 vs 66.50, P=132), forced expiratory volume in the first second (FEV1, 0.93 vs 1.13 L; P=0.001) and FEV1 (%) (28.50 vs 30.50, P=0.605). In addition, patients at older age presented a significantly reduced physical activity capacity, 6MWD (385.93 vs 320.84 m, P<0.001) and IKE (24.75 vs 22.55 kgf, P=0.005), as well as higher values for inflammatory biomarkers, C-reactive protein (8.77 vs 3.34 mg/L, P=0.022). Moreover, patients at older age presented significantly lower score at the cognitive assessment, MoCA (23.50 vs 20.00, P<0.001). Conclusion: Elderly COPD patients have reduced exercise capacity and muscle strength, deteriorated cognitive function and increased inflammatory markers. Furthermore, inflammation markers were significantly correlated with muscle strength, walking distance and cognitive impairment. Keywords: aging, inflammation, strength, pulmonary function
format	article
author	Tudorache E Fildan AP Frandes M Dantes E Tofolean DE
author_facet	Tudorache E Fildan AP Frandes M Dantes E Tofolean DE
author_sort	Tudorache E
title	Aging and extrapulmonary effects of chronic obstructive pulmonary disease
title_short	Aging and extrapulmonary effects of chronic obstructive pulmonary disease
title_full	Aging and extrapulmonary effects of chronic obstructive pulmonary disease
title_fullStr	Aging and extrapulmonary effects of chronic obstructive pulmonary disease
title_full_unstemmed	Aging and extrapulmonary effects of chronic obstructive pulmonary disease
title_sort	aging and extrapulmonary effects of chronic obstructive pulmonary disease
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/af9211ffdf384092ad781d7185246b4c
work_keys_str_mv	AT tudorachee agingandextrapulmonaryeffectsofchronicobstructivepulmonarydisease AT fildanap agingandextrapulmonaryeffectsofchronicobstructivepulmonarydisease AT frandesm agingandextrapulmonaryeffectsofchronicobstructivepulmonarydisease AT dantese agingandextrapulmonaryeffectsofchronicobstructivepulmonarydisease AT tofoleande agingandextrapulmonaryeffectsofchronicobstructivepulmonarydisease
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Aging and extrapulmonary effects of chronic obstructive pulmonary disease

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