Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme. They find that those that do interact with heme possess specific sequence traits that manifest qualities such as increased hydrophobic...

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Autores principales:	Maxime Lecerf, Alexia Kanyavuz, Sofia Rossini, Jordan D. Dimitrov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/af921751134f450894b0f294ada57a9b
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spelling	oai:doaj.org-article:af921751134f450894b0f294ada57a9b2021-12-02T13:24:24ZInteraction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities10.1038/s42003-021-01931-72399-3642https://doaj.org/article/af921751134f450894b0f294ada57a9b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01931-7https://doaj.org/toc/2399-3642Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme. They find that those that do interact with heme possess specific sequence traits that manifest qualities such as increased hydrophobicity, self-binding and intrinsic polyreactivity, thus suggesting that heme interaction is a predictor for therapeutically important qualities.Maxime LecerfAlexia KanyavuzSofia RossiniJordan D. DimitrovNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Maxime Lecerf Alexia Kanyavuz Sofia Rossini Jordan D. Dimitrov Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
description	Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme. They find that those that do interact with heme possess specific sequence traits that manifest qualities such as increased hydrophobicity, self-binding and intrinsic polyreactivity, thus suggesting that heme interaction is a predictor for therapeutically important qualities.
format	article
author	Maxime Lecerf Alexia Kanyavuz Sofia Rossini Jordan D. Dimitrov
author_facet	Maxime Lecerf Alexia Kanyavuz Sofia Rossini Jordan D. Dimitrov
author_sort	Maxime Lecerf
title	Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
title_short	Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
title_full	Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
title_fullStr	Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
title_full_unstemmed	Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
title_sort	interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/af921751134f450894b0f294ada57a9b
work_keys_str_mv	AT maximelecerf interactionofclinicalstageantibodieswithhemepredictstheirphysiochemicalandbindingqualities AT alexiakanyavuz interactionofclinicalstageantibodieswithhemepredictstheirphysiochemicalandbindingqualities AT sofiarossini interactionofclinicalstageantibodieswithhemepredictstheirphysiochemicalandbindingqualities AT jordanddimitrov interactionofclinicalstageantibodieswithhemepredictstheirphysiochemicalandbindingqualities
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Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

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