Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme. They find that those that do interact with heme possess specific sequence traits that manifest qualities such as increased hydrophobic...

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Autores principales: Maxime Lecerf, Alexia Kanyavuz, Sofia Rossini, Jordan D. Dimitrov
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/af921751134f450894b0f294ada57a9b
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