Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? The “Relative” Con Position

Background: Crohn’s disease is a progressive inflammatory bowel disease. Persistent untreated inflammation can cumulatively result in bowel damage in the form of strictures, fistulas, and fibrosis, which can ultimately result in the need for major abdominal surgery. Mucosal healing has emerged as an...

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Autores principales:	Mahmoud Mosli, Turki Alameel, Ala I. Sharara
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	crohn’s disease mucosal healing treatment partial healing Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/af97d2c84dc34b8dabaa12dc83db6a45
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spelling	oai:doaj.org-article:af97d2c84dc34b8dabaa12dc83db6a452021-11-18T11:08:46ZMucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? The “Relative” Con Position2296-94032296-936510.1159/000519731https://doaj.org/article/af97d2c84dc34b8dabaa12dc83db6a452021-10-01T00:00:00Zhttps://www.karger.com/Article/FullText/519731https://doaj.org/toc/2296-9403https://doaj.org/toc/2296-9365Background: Crohn’s disease is a progressive inflammatory bowel disease. Persistent untreated inflammation can cumulatively result in bowel damage in the form of strictures, fistulas, and fibrosis, which can ultimately result in the need for major abdominal surgery. Mucosal healing has emerged as an attractive, yet ambitious goal in the hope of preventing long-term complications. Summary: Clinical remission is an inadequate measure of disease activity. Noninvasive markers such as fecal calprotectin, CRP, or small bowel ultrasound are useful adjunct tools. However, endoscopic assessment remains the cornerstone in building a treatment plan. Achieving complete mucosal healing has proved to be an elusive goal even in the ideal setting of a clinical trial. Key Messages: Aiming for complete mucosal healing in all patients may result in overuse of medications, higher costs, and potential side effects of aggressive immunosuppressive treatment. More practical goals such as relative or partial healing, for example, 50% improvement in inflammation and reduction in size of ulcers, ought to be considered, particularly in difficult-to-treat populations.Mahmoud MosliTurki AlameelAla I. ShararaKarger Publishersarticlecrohn’s diseasemucosal healingtreatmentpartial healingDiseases of the digestive system. GastroenterologyRC799-869ENInflammatory Intestinal Diseases, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	crohn’s disease mucosal healing treatment partial healing Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	crohn’s disease mucosal healing treatment partial healing Diseases of the digestive system. Gastroenterology RC799-869 Mahmoud Mosli Turki Alameel Ala I. Sharara Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? The “Relative” Con Position
description	Background: Crohn’s disease is a progressive inflammatory bowel disease. Persistent untreated inflammation can cumulatively result in bowel damage in the form of strictures, fistulas, and fibrosis, which can ultimately result in the need for major abdominal surgery. Mucosal healing has emerged as an attractive, yet ambitious goal in the hope of preventing long-term complications. Summary: Clinical remission is an inadequate measure of disease activity. Noninvasive markers such as fecal calprotectin, CRP, or small bowel ultrasound are useful adjunct tools. However, endoscopic assessment remains the cornerstone in building a treatment plan. Achieving complete mucosal healing has proved to be an elusive goal even in the ideal setting of a clinical trial. Key Messages: Aiming for complete mucosal healing in all patients may result in overuse of medications, higher costs, and potential side effects of aggressive immunosuppressive treatment. More practical goals such as relative or partial healing, for example, 50% improvement in inflammation and reduction in size of ulcers, ought to be considered, particularly in difficult-to-treat populations.
format	article
author	Mahmoud Mosli Turki Alameel Ala I. Sharara
author_facet	Mahmoud Mosli Turki Alameel Ala I. Sharara
author_sort	Mahmoud Mosli
title	Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? The “Relative” Con Position
title_short	Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? The “Relative” Con Position
title_full	Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? The “Relative” Con Position
title_fullStr	Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? The “Relative” Con Position
title_full_unstemmed	Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? The “Relative” Con Position
title_sort	mucosal healing in crohn’s disease: bull’s eye or bust? the “relative” con position
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/af97d2c84dc34b8dabaa12dc83db6a45
work_keys_str_mv	AT mahmoudmosli mucosalhealingincrohnsdiseasebullseyeorbusttherelativeconposition AT turkialameel mucosalhealingincrohnsdiseasebullseyeorbusttherelativeconposition AT alaisharara mucosalhealingincrohnsdiseasebullseyeorbusttherelativeconposition
_version_	1718420865199112192

Mucosal Healing in Crohn’s Disease: Bull’s Eye or Bust? The “Relative” Con Position

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