Behavioral effects of continuous theta-burst stimulation in macaque parietal cortex

Abstract The neural mechanisms underlying the effects of continuous Theta-Burst Stimulation (cTBS) in humans are poorly understood. Animal studies can clarify the effects of cTBS on individual neurons, but behavioral evidence is necessary to demonstrate the validity of the animal model. We investiga...

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Autores principales:	Lara Merken, Marco Davare, Peter Janssen, Maria C. Romero
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/af9951e6ed9c41e085a1f87777c3a306
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spelling	oai:doaj.org-article:af9951e6ed9c41e085a1f87777c3a3062021-12-02T11:37:25ZBehavioral effects of continuous theta-burst stimulation in macaque parietal cortex10.1038/s41598-021-83904-82045-2322https://doaj.org/article/af9951e6ed9c41e085a1f87777c3a3062021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83904-8https://doaj.org/toc/2045-2322Abstract The neural mechanisms underlying the effects of continuous Theta-Burst Stimulation (cTBS) in humans are poorly understood. Animal studies can clarify the effects of cTBS on individual neurons, but behavioral evidence is necessary to demonstrate the validity of the animal model. We investigated the behavioral effect of cTBS applied over parietal cortex in rhesus monkeys performing a visually-guided grasping task with two differently sized objects, which required either a power grip or a pad-to-side grip. We used Fitts’ law, predicting shorter grasping times (GT) for large compared to small objects, to investigate cTBS effects on two different grip types. cTBS induced long-lasting object-specific and dose-dependent changes in GT that remained present for up to two hours. High-intensity cTBS increased GTs for a power grip, but shortened GTs for a pad-to-side grip. Thus, high-intensity stimulation strongly reduced the natural GT difference between objects (i.e. the Fitts’ law effect). In contrast, low-intensity cTBS induced the opposite effects on GT. Modifying the coil orientation from the standard 45-degree to a 30-degree angle induced opposite cTBS effects on GT. These findings represent behavioral evidence for the validity of the nonhuman primate model to study the neural underpinnings of non-invasive brain stimulation.Lara MerkenMarco DavarePeter JanssenMaria C. RomeroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lara Merken Marco Davare Peter Janssen Maria C. Romero Behavioral effects of continuous theta-burst stimulation in macaque parietal cortex
description	Abstract The neural mechanisms underlying the effects of continuous Theta-Burst Stimulation (cTBS) in humans are poorly understood. Animal studies can clarify the effects of cTBS on individual neurons, but behavioral evidence is necessary to demonstrate the validity of the animal model. We investigated the behavioral effect of cTBS applied over parietal cortex in rhesus monkeys performing a visually-guided grasping task with two differently sized objects, which required either a power grip or a pad-to-side grip. We used Fitts’ law, predicting shorter grasping times (GT) for large compared to small objects, to investigate cTBS effects on two different grip types. cTBS induced long-lasting object-specific and dose-dependent changes in GT that remained present for up to two hours. High-intensity cTBS increased GTs for a power grip, but shortened GTs for a pad-to-side grip. Thus, high-intensity stimulation strongly reduced the natural GT difference between objects (i.e. the Fitts’ law effect). In contrast, low-intensity cTBS induced the opposite effects on GT. Modifying the coil orientation from the standard 45-degree to a 30-degree angle induced opposite cTBS effects on GT. These findings represent behavioral evidence for the validity of the nonhuman primate model to study the neural underpinnings of non-invasive brain stimulation.
format	article
author	Lara Merken Marco Davare Peter Janssen Maria C. Romero
author_facet	Lara Merken Marco Davare Peter Janssen Maria C. Romero
author_sort	Lara Merken
title	Behavioral effects of continuous theta-burst stimulation in macaque parietal cortex
title_short	Behavioral effects of continuous theta-burst stimulation in macaque parietal cortex
title_full	Behavioral effects of continuous theta-burst stimulation in macaque parietal cortex
title_fullStr	Behavioral effects of continuous theta-burst stimulation in macaque parietal cortex
title_full_unstemmed	Behavioral effects of continuous theta-burst stimulation in macaque parietal cortex
title_sort	behavioral effects of continuous theta-burst stimulation in macaque parietal cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/af9951e6ed9c41e085a1f87777c3a306
work_keys_str_mv	AT laramerken behavioraleffectsofcontinuousthetaburststimulationinmacaqueparietalcortex AT marcodavare behavioraleffectsofcontinuousthetaburststimulationinmacaqueparietalcortex AT peterjanssen behavioraleffectsofcontinuousthetaburststimulationinmacaqueparietalcortex AT mariacromero behavioraleffectsofcontinuousthetaburststimulationinmacaqueparietalcortex
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Behavioral effects of continuous theta-burst stimulation in macaque parietal cortex

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