Glucocorticoid receptor signalling activates YAP in breast cancer

Activation of YAP contributes to tumorigenesis in several tissues. Here, the authors show that in breast cancer cells glucocorticoids induce expression of fibronectin that in turn activates focal adhesion kinase/Src signalling to promote YAP nuclear translocation and transcriptional activity.

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Autores principales:	Giovanni Sorrentino, Naomi Ruggeri, Alessandro Zannini, Eleonora Ingallina, Rebecca Bertolio, Carolina Marotta, Carmelo Neri, Elisa Cappuzzello, Mattia Forcato, Antonio Rosato, Miguel Mano, Silvio Bicciato, Giannino Del Sal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/afa17ad9724040a88cf693824087cda3
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spelling	oai:doaj.org-article:afa17ad9724040a88cf693824087cda32021-12-02T14:42:06ZGlucocorticoid receptor signalling activates YAP in breast cancer10.1038/ncomms140732041-1723https://doaj.org/article/afa17ad9724040a88cf693824087cda32017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14073https://doaj.org/toc/2041-1723Activation of YAP contributes to tumorigenesis in several tissues. Here, the authors show that in breast cancer cells glucocorticoids induce expression of fibronectin that in turn activates focal adhesion kinase/Src signalling to promote YAP nuclear translocation and transcriptional activity.Giovanni SorrentinoNaomi RuggeriAlessandro ZanniniEleonora IngallinaRebecca BertolioCarolina MarottaCarmelo NeriElisa CappuzzelloMattia ForcatoAntonio RosatoMiguel ManoSilvio BicciatoGiannino Del SalNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giovanni Sorrentino Naomi Ruggeri Alessandro Zannini Eleonora Ingallina Rebecca Bertolio Carolina Marotta Carmelo Neri Elisa Cappuzzello Mattia Forcato Antonio Rosato Miguel Mano Silvio Bicciato Giannino Del Sal Glucocorticoid receptor signalling activates YAP in breast cancer
description	Activation of YAP contributes to tumorigenesis in several tissues. Here, the authors show that in breast cancer cells glucocorticoids induce expression of fibronectin that in turn activates focal adhesion kinase/Src signalling to promote YAP nuclear translocation and transcriptional activity.
format	article
author	Giovanni Sorrentino Naomi Ruggeri Alessandro Zannini Eleonora Ingallina Rebecca Bertolio Carolina Marotta Carmelo Neri Elisa Cappuzzello Mattia Forcato Antonio Rosato Miguel Mano Silvio Bicciato Giannino Del Sal
author_facet	Giovanni Sorrentino Naomi Ruggeri Alessandro Zannini Eleonora Ingallina Rebecca Bertolio Carolina Marotta Carmelo Neri Elisa Cappuzzello Mattia Forcato Antonio Rosato Miguel Mano Silvio Bicciato Giannino Del Sal
author_sort	Giovanni Sorrentino
title	Glucocorticoid receptor signalling activates YAP in breast cancer
title_short	Glucocorticoid receptor signalling activates YAP in breast cancer
title_full	Glucocorticoid receptor signalling activates YAP in breast cancer
title_fullStr	Glucocorticoid receptor signalling activates YAP in breast cancer
title_full_unstemmed	Glucocorticoid receptor signalling activates YAP in breast cancer
title_sort	glucocorticoid receptor signalling activates yap in breast cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/afa17ad9724040a88cf693824087cda3
work_keys_str_mv	AT giovannisorrentino glucocorticoidreceptorsignallingactivatesyapinbreastcancer AT naomiruggeri glucocorticoidreceptorsignallingactivatesyapinbreastcancer AT alessandrozannini glucocorticoidreceptorsignallingactivatesyapinbreastcancer AT eleonoraingallina glucocorticoidreceptorsignallingactivatesyapinbreastcancer AT rebeccabertolio glucocorticoidreceptorsignallingactivatesyapinbreastcancer AT carolinamarotta glucocorticoidreceptorsignallingactivatesyapinbreastcancer AT carmeloneri glucocorticoidreceptorsignallingactivatesyapinbreastcancer AT elisacappuzzello glucocorticoidreceptorsignallingactivatesyapinbreastcancer AT mattiaforcato glucocorticoidreceptorsignallingactivatesyapinbreastcancer AT antoniorosato glucocorticoidreceptorsignallingactivatesyapinbreastcancer AT miguelmano glucocorticoidreceptorsignallingactivatesyapinbreastcancer AT silviobicciato glucocorticoidreceptorsignallingactivatesyapinbreastcancer AT gianninodelsal glucocorticoidreceptorsignallingactivatesyapinbreastcancer
_version_	1718389830837075968

Glucocorticoid receptor signalling activates YAP in breast cancer

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