Prioritizing Parkinson’s disease genes using population-scale transcriptomic data

GWAS have identified over 41 susceptibility loci for Parkinson’s disease (PD). Here, the authors integrate PD GWAS summary statistics with transcriptome data from monocytes and DLFPC tissue in a TWAS approach and find 66 significant associations with PD risk highlighting lysosomal and innate immune...

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Autores principales:	Yang I. Li, Garrett Wong, Jack Humphrey, Towfique Raj
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/afa344da02c74e3c8e6b3f277a5732e4
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id	oai:doaj.org-article:afa344da02c74e3c8e6b3f277a5732e4
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spelling	oai:doaj.org-article:afa344da02c74e3c8e6b3f277a5732e42021-12-02T15:35:26ZPrioritizing Parkinson’s disease genes using population-scale transcriptomic data10.1038/s41467-019-08912-92041-1723https://doaj.org/article/afa344da02c74e3c8e6b3f277a5732e42019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08912-9https://doaj.org/toc/2041-1723GWAS have identified over 41 susceptibility loci for Parkinson’s disease (PD). Here, the authors integrate PD GWAS summary statistics with transcriptome data from monocytes and DLFPC tissue in a TWAS approach and find 66 significant associations with PD risk highlighting lysosomal and innate immune functions.Yang I. LiGarrett WongJack HumphreyTowfique RajNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang I. Li Garrett Wong Jack Humphrey Towfique Raj Prioritizing Parkinson’s disease genes using population-scale transcriptomic data
description	GWAS have identified over 41 susceptibility loci for Parkinson’s disease (PD). Here, the authors integrate PD GWAS summary statistics with transcriptome data from monocytes and DLFPC tissue in a TWAS approach and find 66 significant associations with PD risk highlighting lysosomal and innate immune functions.
format	article
author	Yang I. Li Garrett Wong Jack Humphrey Towfique Raj
author_facet	Yang I. Li Garrett Wong Jack Humphrey Towfique Raj
author_sort	Yang I. Li
title	Prioritizing Parkinson’s disease genes using population-scale transcriptomic data
title_short	Prioritizing Parkinson’s disease genes using population-scale transcriptomic data
title_full	Prioritizing Parkinson’s disease genes using population-scale transcriptomic data
title_fullStr	Prioritizing Parkinson’s disease genes using population-scale transcriptomic data
title_full_unstemmed	Prioritizing Parkinson’s disease genes using population-scale transcriptomic data
title_sort	prioritizing parkinson’s disease genes using population-scale transcriptomic data
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/afa344da02c74e3c8e6b3f277a5732e4
work_keys_str_mv	AT yangili prioritizingparkinsonsdiseasegenesusingpopulationscaletranscriptomicdata AT garrettwong prioritizingparkinsonsdiseasegenesusingpopulationscaletranscriptomicdata AT jackhumphrey prioritizingparkinsonsdiseasegenesusingpopulationscaletranscriptomicdata AT towfiqueraj prioritizingparkinsonsdiseasegenesusingpopulationscaletranscriptomicdata
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Prioritizing Parkinson’s disease genes using population-scale transcriptomic data

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