Clump sequencing exposes the spatial expression programs of intestinal secretory cells

Combining scRNA-seq with spatial information to enable the reconstruction of spatially-resolved cell atlases is challenging for rare cell types. Here the authors present ClumpSeq, an approach for sequencing small clumps of tissue attached cells, and apply it to establish spatial atlases for all secr...

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Main Authors:	Rita Manco, Inna Averbukh, Ziv Porat, Keren Bahar Halpern, Ido Amit, Shalev Itzkovitz
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/afa3c10f1b32444b80e1d582eef76aa2
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id	oai:doaj.org-article:afa3c10f1b32444b80e1d582eef76aa2
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spelling	oai:doaj.org-article:afa3c10f1b32444b80e1d582eef76aa22021-12-02T15:49:49ZClump sequencing exposes the spatial expression programs of intestinal secretory cells10.1038/s41467-021-23245-22041-1723https://doaj.org/article/afa3c10f1b32444b80e1d582eef76aa22021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23245-2https://doaj.org/toc/2041-1723Combining scRNA-seq with spatial information to enable the reconstruction of spatially-resolved cell atlases is challenging for rare cell types. Here the authors present ClumpSeq, an approach for sequencing small clumps of tissue attached cells, and apply it to establish spatial atlases for all secretory cell types in the small intestine.Rita MancoInna AverbukhZiv PoratKeren Bahar HalpernIdo AmitShalev ItzkovitzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rita Manco Inna Averbukh Ziv Porat Keren Bahar Halpern Ido Amit Shalev Itzkovitz Clump sequencing exposes the spatial expression programs of intestinal secretory cells
description	Combining scRNA-seq with spatial information to enable the reconstruction of spatially-resolved cell atlases is challenging for rare cell types. Here the authors present ClumpSeq, an approach for sequencing small clumps of tissue attached cells, and apply it to establish spatial atlases for all secretory cell types in the small intestine.
format	article
author	Rita Manco Inna Averbukh Ziv Porat Keren Bahar Halpern Ido Amit Shalev Itzkovitz
author_facet	Rita Manco Inna Averbukh Ziv Porat Keren Bahar Halpern Ido Amit Shalev Itzkovitz
author_sort	Rita Manco
title	Clump sequencing exposes the spatial expression programs of intestinal secretory cells
title_short	Clump sequencing exposes the spatial expression programs of intestinal secretory cells
title_full	Clump sequencing exposes the spatial expression programs of intestinal secretory cells
title_fullStr	Clump sequencing exposes the spatial expression programs of intestinal secretory cells
title_full_unstemmed	Clump sequencing exposes the spatial expression programs of intestinal secretory cells
title_sort	clump sequencing exposes the spatial expression programs of intestinal secretory cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/afa3c10f1b32444b80e1d582eef76aa2
work_keys_str_mv	AT ritamanco clumpsequencingexposesthespatialexpressionprogramsofintestinalsecretorycells AT innaaverbukh clumpsequencingexposesthespatialexpressionprogramsofintestinalsecretorycells AT zivporat clumpsequencingexposesthespatialexpressionprogramsofintestinalsecretorycells AT kerenbaharhalpern clumpsequencingexposesthespatialexpressionprogramsofintestinalsecretorycells AT idoamit clumpsequencingexposesthespatialexpressionprogramsofintestinalsecretorycells AT shalevitzkovitz clumpsequencingexposesthespatialexpressionprogramsofintestinalsecretorycells
_version_	1718385711841804288

Clump sequencing exposes the spatial expression programs of intestinal secretory cells

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