Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals

Mucosal-associated invariant T (MAIT) cells are key in immunity and diseases, but how their effector polarization is controlled is still unclear. Here, the authors show that an IL-1β/IL-23/mTORC2 axis is essential for the induction of IL-17-producing MAIT17, while an IL-2/IL-15/mTORC1 axis is import...

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Autores principales:	Huishan Tao, Yun Pan, Shuai Chu, Lei Li, Jinhai Xie, Peng Wang, Shimeng Zhang, Srija Reddy, John W. Sleasman, Xiao-Ping Zhong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/afa474b68bac49b9b203db77650e34fc
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spelling	oai:doaj.org-article:afa474b68bac49b9b203db77650e34fc2021-12-02T13:26:23ZDifferential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals10.1038/s41467-021-22162-82041-1723https://doaj.org/article/afa474b68bac49b9b203db77650e34fc2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22162-8https://doaj.org/toc/2041-1723Mucosal-associated invariant T (MAIT) cells are key in immunity and diseases, but how their effector polarization is controlled is still unclear. Here, the authors show that an IL-1β/IL-23/mTORC2 axis is essential for the induction of IL-17-producing MAIT17, while an IL-2/IL-15/mTORC1 axis is important for the homeostasis of IFN-γ-producing MAIT1.Huishan TaoYun PanShuai ChuLei LiJinhai XiePeng WangShimeng ZhangSrija ReddyJohn W. SleasmanXiao-Ping ZhongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huishan Tao Yun Pan Shuai Chu Lei Li Jinhai Xie Peng Wang Shimeng Zhang Srija Reddy John W. Sleasman Xiao-Ping Zhong Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals
description	Mucosal-associated invariant T (MAIT) cells are key in immunity and diseases, but how their effector polarization is controlled is still unclear. Here, the authors show that an IL-1β/IL-23/mTORC2 axis is essential for the induction of IL-17-producing MAIT17, while an IL-2/IL-15/mTORC1 axis is important for the homeostasis of IFN-γ-producing MAIT1.
format	article
author	Huishan Tao Yun Pan Shuai Chu Lei Li Jinhai Xie Peng Wang Shimeng Zhang Srija Reddy John W. Sleasman Xiao-Ping Zhong
author_facet	Huishan Tao Yun Pan Shuai Chu Lei Li Jinhai Xie Peng Wang Shimeng Zhang Srija Reddy John W. Sleasman Xiao-Ping Zhong
author_sort	Huishan Tao
title	Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals
title_short	Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals
title_full	Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals
title_fullStr	Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals
title_full_unstemmed	Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals
title_sort	differential controls of mait cell effector polarization by mtorc1/mtorc2 via integrating cytokine and costimulatory signals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/afa474b68bac49b9b203db77650e34fc
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Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals

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