DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

Cell cycle arrest after DNA damage is achieved by the expression of the CDK inhibitor p21. Here the authors show that spontaneous DNA damage incurred in unperturbed cell cycles, leads to cell populations exhibiting a bistable state, with p53 and p21 regulating the proliferation-quiescence decision.

Guardado en:

Detalles Bibliográficos
Autores principales:	Alexis R. Barr, Samuel Cooper, Frank S. Heldt, Francesca Butera, Henriette Stoy, Jörg Mansfeld, Béla Novák, Chris Bakal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/afa56ee404454f3788fc31b2ea96dc7a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:afa56ee404454f3788fc31b2ea96dc7a
record_format	dspace
spelling	oai:doaj.org-article:afa56ee404454f3788fc31b2ea96dc7a2021-12-02T14:42:18ZDNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression10.1038/ncomms147282041-1723https://doaj.org/article/afa56ee404454f3788fc31b2ea96dc7a2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14728https://doaj.org/toc/2041-1723Cell cycle arrest after DNA damage is achieved by the expression of the CDK inhibitor p21. Here the authors show that spontaneous DNA damage incurred in unperturbed cell cycles, leads to cell populations exhibiting a bistable state, with p53 and p21 regulating the proliferation-quiescence decision.Alexis R. BarrSamuel CooperFrank S. HeldtFrancesca ButeraHenriette StoyJörg MansfeldBéla NovákChris BakalNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexis R. Barr Samuel Cooper Frank S. Heldt Francesca Butera Henriette Stoy Jörg Mansfeld Béla Novák Chris Bakal DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression
description	Cell cycle arrest after DNA damage is achieved by the expression of the CDK inhibitor p21. Here the authors show that spontaneous DNA damage incurred in unperturbed cell cycles, leads to cell populations exhibiting a bistable state, with p53 and p21 regulating the proliferation-quiescence decision.
format	article
author	Alexis R. Barr Samuel Cooper Frank S. Heldt Francesca Butera Henriette Stoy Jörg Mansfeld Béla Novák Chris Bakal
author_facet	Alexis R. Barr Samuel Cooper Frank S. Heldt Francesca Butera Henriette Stoy Jörg Mansfeld Béla Novák Chris Bakal
author_sort	Alexis R. Barr
title	DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression
title_short	DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression
title_full	DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression
title_fullStr	DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression
title_full_unstemmed	DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression
title_sort	dna damage during s-phase mediates the proliferation-quiescence decision in the subsequent g1 via p21 expression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/afa56ee404454f3788fc31b2ea96dc7a
work_keys_str_mv	AT alexisrbarr dnadamageduringsphasemediatestheproliferationquiescencedecisioninthesubsequentg1viap21expression AT samuelcooper dnadamageduringsphasemediatestheproliferationquiescencedecisioninthesubsequentg1viap21expression AT franksheldt dnadamageduringsphasemediatestheproliferationquiescencedecisioninthesubsequentg1viap21expression AT francescabutera dnadamageduringsphasemediatestheproliferationquiescencedecisioninthesubsequentg1viap21expression AT henriettestoy dnadamageduringsphasemediatestheproliferationquiescencedecisioninthesubsequentg1viap21expression AT jorgmansfeld dnadamageduringsphasemediatestheproliferationquiescencedecisioninthesubsequentg1viap21expression AT belanovak dnadamageduringsphasemediatestheproliferationquiescencedecisioninthesubsequentg1viap21expression AT chrisbakal dnadamageduringsphasemediatestheproliferationquiescencedecisioninthesubsequentg1viap21expression
_version_	1718389772394692608

DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

Ejemplares similares