T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis

ABSTRACT Although classically associated with myelopoiesis, granulocyte-macrophage colony-stimulating factor (GM-CSF) is increasingly recognized as being important for tuberculosis (TB) resistance. GM-CSF is expressed by nonhematopoietic and hematopoietic lineages following infection with Mycobacter...

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Autor principal:	Richard T. Robinson
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	CSF2 GM-CSF GMCSF immune mycobacteria tuberculosis Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/afa5dc82305b4123aa5f4d332f6b36ac
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spelling	oai:doaj.org-article:afa5dc82305b4123aa5f4d332f6b36ac2021-11-15T15:51:56ZT Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis10.1128/mBio.02087-172150-7511https://doaj.org/article/afa5dc82305b4123aa5f4d332f6b36ac2017-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02087-17https://doaj.org/toc/2150-7511ABSTRACT Although classically associated with myelopoiesis, granulocyte-macrophage colony-stimulating factor (GM-CSF) is increasingly recognized as being important for tuberculosis (TB) resistance. GM-CSF is expressed by nonhematopoietic and hematopoietic lineages following infection with Mycobacterium tuberculosis and is necessary to restrict M. tuberculosis growth in experimental models. Until the recent study by Rothchild et al. (mBio 8:e01514-17, 2017, https://doi.org/10.1128/mBio.01514-17 ), it was unknown whether GM-CSF-producing T cells contribute to TB resistance. Rothchild et al. identify which conventional and nonconventional T cell subsets produce GM-CSF during experimental TB, establish their protective nature using a variety of approaches, and provide a mechanistic basis for their ability to restrict M. tuberculosis growth. This commentary discusses the significance of these findings to basic and applied TB research. As translated to human disease, these findings suggest vaccine-mediated expansion of GM-CSF-producing T cells could be an effective prophylactic or therapeutic TB strategy.Richard T. RobinsonAmerican Society for MicrobiologyarticleCSF2GM-CSFGMCSFimmunemycobacteriatuberculosisMicrobiologyQR1-502ENmBio, Vol 8, Iss 6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	CSF2 GM-CSF GMCSF immune mycobacteria tuberculosis Microbiology QR1-502
spellingShingle	CSF2 GM-CSF GMCSF immune mycobacteria tuberculosis Microbiology QR1-502 Richard T. Robinson T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis
description	ABSTRACT Although classically associated with myelopoiesis, granulocyte-macrophage colony-stimulating factor (GM-CSF) is increasingly recognized as being important for tuberculosis (TB) resistance. GM-CSF is expressed by nonhematopoietic and hematopoietic lineages following infection with Mycobacterium tuberculosis and is necessary to restrict M. tuberculosis growth in experimental models. Until the recent study by Rothchild et al. (mBio 8:e01514-17, 2017, https://doi.org/10.1128/mBio.01514-17 ), it was unknown whether GM-CSF-producing T cells contribute to TB resistance. Rothchild et al. identify which conventional and nonconventional T cell subsets produce GM-CSF during experimental TB, establish their protective nature using a variety of approaches, and provide a mechanistic basis for their ability to restrict M. tuberculosis growth. This commentary discusses the significance of these findings to basic and applied TB research. As translated to human disease, these findings suggest vaccine-mediated expansion of GM-CSF-producing T cells could be an effective prophylactic or therapeutic TB strategy.
format	article
author	Richard T. Robinson
author_facet	Richard T. Robinson
author_sort	Richard T. Robinson
title	T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis
title_short	T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis
title_full	T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis
title_fullStr	T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis
title_full_unstemmed	T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis
title_sort	t cell production of gm-csf protects the host during experimental tuberculosis
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/afa5dc82305b4123aa5f4d332f6b36ac
work_keys_str_mv	AT richardtrobinson tcellproductionofgmcsfprotectsthehostduringexperimentaltuberculosis
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T Cell Production of GM-CSF Protects the Host during Experimental Tuberculosis

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