Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery

Henry M Smilowitz,1 Alexandria Meyers,1 Khalil Rahman,1 Nathaniel A Dyment,2 Dan Sasso,1 Crystal Xue,3 Douglas L Oliver,4 Alexander Lichtler,5 Xiaomeng Deng,6 Sharif M Ridwan,1 Lauren J Tarmu,7,8 Qian Wu,9 Andrew L Salner,10 Ketan R Bulsara,11 Daniel N Slatkin,12 James F Hainfeld12 1Department of C...

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Autores principales:	Smilowitz HM, Meyers A, Rahman K, Dyment NA, Sasso D, Xue C, Oliver DL, Lichtler A, Deng X, Ridwan SM, Tarmu LJ, Wu Q, Salner AL, Bulsara KR, Slatkin DN, Hainfeld JF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Gold Nanoparticles Glioma Edema IV injection Convection Enhanced Delivery Fluorescence Microscopy Gold Enhance Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/afa780381865487aac2d5f47ba07a3b8
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spelling	oai:doaj.org-article:afa780381865487aac2d5f47ba07a3b82021-12-02T07:16:29ZIntravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery1178-2013https://doaj.org/article/afa780381865487aac2d5f47ba07a3b82018-07-01T00:00:00Zhttps://www.dovepress.com/intravenously-injected-gold-nanoparticles-aunps-access-intracerebral-f-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Henry M Smilowitz,1 Alexandria Meyers,1 Khalil Rahman,1 Nathaniel A Dyment,2 Dan Sasso,1 Crystal Xue,3 Douglas L Oliver,4 Alexander Lichtler,5 Xiaomeng Deng,6 Sharif M Ridwan,1 Lauren J Tarmu,7,8 Qian Wu,9 Andrew L Salner,10 Ketan R Bulsara,11 Daniel N Slatkin,12 James F Hainfeld12 1Department of Cell Biology, University of Connecticut Health Center, Farmington, CT, 2Department of Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA, 3George Washington University School of Medicine, Washington, DC, 4Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, 5Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT, 6David Geffen School of Medicine at UCLA, Student Affairs Office, Los Angeles, CA, 7Department of Human Behavior, College of Southern Nevada, 8Department of Anthropology, University of Nevada, Las Vegas, NV, 9Department of Anatomic Pathology, University of Connecticut Health Center, Farmington, 10The Gray Cancer Center, Hartford Hospital, Hartford, 11Division of Neurosurgery, UConn Health, Farmington, CT, 12Nanoprobes, Inc, Yaphank, NY, USA Background: Intravenously (IV)-injected gold nanoparticles (AuNPs) powerfully enhance the efficacy of X-ray therapy of tumors including advanced gliomas. However, pharmacokinetic issues, such as slow tissue clearance and skin discoloration, may impede clinical translation. The direct infusion of AuNPs into the tumor might be an alternative mode of delivery. Materials and methods: Using the advanced, invasive, and difficult-to-treat F98 rat glioma model, we have studied the biodistribution of the AuNPs in the tumor and surrounding brain after either IV injection or direct intratumoral infusion by convection-enhanced delivery using light microscopy immunofluorescence and direct gold visualization. Results: IV-injected AuNPs localize more specifically to intracerebral tumor cells, both in the main tumor mass and in the migrated tumor cells as well as the tumor edema, than do the directly infused AuNPs. Although some of the directly infused AuNPs do access the main tumor region, such access is largely restricted. Conclusion: These data suggest that IV-injected AuNPs are likely to have a greater therapeutic benefit when combined with radiation therapy than after the direct infusion of AuNPs. Keywords: gold nanoparticles, glioma, edema, IV injection, convection-enhanced delivery, fluorescence microscopy, gold enhanceSmilowitz HMMeyers ARahman KDyment NASasso DXue COliver DLLichtler ADeng XRidwan SMTarmu LJWu QSalner ALBulsara KRSlatkin DNHainfeld JFDove Medical PressarticleGold NanoparticlesGliomaEdemaIV injectionConvection Enhanced DeliveryFluorescence MicroscopyGold EnhanceMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 3937-3948 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gold Nanoparticles Glioma Edema IV injection Convection Enhanced Delivery Fluorescence Microscopy Gold Enhance Medicine (General) R5-920
spellingShingle	Gold Nanoparticles Glioma Edema IV injection Convection Enhanced Delivery Fluorescence Microscopy Gold Enhance Medicine (General) R5-920 Smilowitz HM Meyers A Rahman K Dyment NA Sasso D Xue C Oliver DL Lichtler A Deng X Ridwan SM Tarmu LJ Wu Q Salner AL Bulsara KR Slatkin DN Hainfeld JF Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery
description	Henry M Smilowitz,1 Alexandria Meyers,1 Khalil Rahman,1 Nathaniel A Dyment,2 Dan Sasso,1 Crystal Xue,3 Douglas L Oliver,4 Alexander Lichtler,5 Xiaomeng Deng,6 Sharif M Ridwan,1 Lauren J Tarmu,7,8 Qian Wu,9 Andrew L Salner,10 Ketan R Bulsara,11 Daniel N Slatkin,12 James F Hainfeld12 1Department of Cell Biology, University of Connecticut Health Center, Farmington, CT, 2Department of Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA, 3George Washington University School of Medicine, Washington, DC, 4Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, 5Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT, 6David Geffen School of Medicine at UCLA, Student Affairs Office, Los Angeles, CA, 7Department of Human Behavior, College of Southern Nevada, 8Department of Anthropology, University of Nevada, Las Vegas, NV, 9Department of Anatomic Pathology, University of Connecticut Health Center, Farmington, 10The Gray Cancer Center, Hartford Hospital, Hartford, 11Division of Neurosurgery, UConn Health, Farmington, CT, 12Nanoprobes, Inc, Yaphank, NY, USA Background: Intravenously (IV)-injected gold nanoparticles (AuNPs) powerfully enhance the efficacy of X-ray therapy of tumors including advanced gliomas. However, pharmacokinetic issues, such as slow tissue clearance and skin discoloration, may impede clinical translation. The direct infusion of AuNPs into the tumor might be an alternative mode of delivery. Materials and methods: Using the advanced, invasive, and difficult-to-treat F98 rat glioma model, we have studied the biodistribution of the AuNPs in the tumor and surrounding brain after either IV injection or direct intratumoral infusion by convection-enhanced delivery using light microscopy immunofluorescence and direct gold visualization. Results: IV-injected AuNPs localize more specifically to intracerebral tumor cells, both in the main tumor mass and in the migrated tumor cells as well as the tumor edema, than do the directly infused AuNPs. Although some of the directly infused AuNPs do access the main tumor region, such access is largely restricted. Conclusion: These data suggest that IV-injected AuNPs are likely to have a greater therapeutic benefit when combined with radiation therapy than after the direct infusion of AuNPs. Keywords: gold nanoparticles, glioma, edema, IV injection, convection-enhanced delivery, fluorescence microscopy, gold enhance
format	article
author	Smilowitz HM Meyers A Rahman K Dyment NA Sasso D Xue C Oliver DL Lichtler A Deng X Ridwan SM Tarmu LJ Wu Q Salner AL Bulsara KR Slatkin DN Hainfeld JF
author_facet	Smilowitz HM Meyers A Rahman K Dyment NA Sasso D Xue C Oliver DL Lichtler A Deng X Ridwan SM Tarmu LJ Wu Q Salner AL Bulsara KR Slatkin DN Hainfeld JF
author_sort	Smilowitz HM
title	Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery
title_short	Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery
title_full	Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery
title_fullStr	Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery
title_full_unstemmed	Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery
title_sort	intravenously-injected gold nanoparticles (aunps) access intracerebral f98 rat gliomas better than aunps infused directly into the tumor site by convection enhanced delivery
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/afa780381865487aac2d5f47ba07a3b8
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Intravenously-injected gold nanoparticles (AuNPs) access intracerebral F98 rat gliomas better than AuNPs infused directly into the tumor site by convection enhanced delivery

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