Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis

Disruption of the microbiota–gut–brain axis results in a wide range of pathologies that are affected, from the brain to the intestine. Gut hormones released by enteroendocrine cells to the gastrointestinal (GI) tract are important signaling molecules within this axis. In the search for the language...

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Autores principales:	Elena Layunta, Berta Buey, Jose Emilio Mesonero, Eva Latorre
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	serotonin 5-HT tryptophan microorganisms PRRs TLRs Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/afa7a2f4f69f4d958a373502d21ec847
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spelling	oai:doaj.org-article:afa7a2f4f69f4d958a373502d21ec8472021-11-08T13:26:07ZCrosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis1664-239210.3389/fendo.2021.748254https://doaj.org/article/afa7a2f4f69f4d958a373502d21ec8472021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.748254/fullhttps://doaj.org/toc/1664-2392Disruption of the microbiota–gut–brain axis results in a wide range of pathologies that are affected, from the brain to the intestine. Gut hormones released by enteroendocrine cells to the gastrointestinal (GI) tract are important signaling molecules within this axis. In the search for the language that allows microbiota to communicate with the gut and the brain, serotonin seems to be the most important mediator. In recent years, serotonin has emerged as a key neurotransmitter in the gut–brain axis because it largely contributes to both GI and brain physiology. In addition, intestinal microbiota are crucial in serotonin signaling, which gives more relevance to the role of the serotonin as an important mediator in microbiota–host interactions. Despite the numerous investigations focused on the gut–brain axis and the pathologies associated, little is known regarding how serotonin can mediate in the microbiota–gut–brain axis. In this review, we will mainly discuss serotonergic system modulation by microbiota as a pathway of communication between intestinal microbes and the body on the microbiota–gut–brain axis, and we explore novel therapeutic approaches for GI diseases and mental disorders.Elena LayuntaElena LayuntaBerta BueyJose Emilio MesoneroJose Emilio MesoneroJose Emilio MesoneroEva LatorreEva LatorreEva LatorreFrontiers Media S.A.articleserotonin5-HTtryptophanmicroorganismsPRRsTLRsDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	serotonin 5-HT tryptophan microorganisms PRRs TLRs Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	serotonin 5-HT tryptophan microorganisms PRRs TLRs Diseases of the endocrine glands. Clinical endocrinology RC648-665 Elena Layunta Elena Layunta Berta Buey Jose Emilio Mesonero Jose Emilio Mesonero Jose Emilio Mesonero Eva Latorre Eva Latorre Eva Latorre Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis
description	Disruption of the microbiota–gut–brain axis results in a wide range of pathologies that are affected, from the brain to the intestine. Gut hormones released by enteroendocrine cells to the gastrointestinal (GI) tract are important signaling molecules within this axis. In the search for the language that allows microbiota to communicate with the gut and the brain, serotonin seems to be the most important mediator. In recent years, serotonin has emerged as a key neurotransmitter in the gut–brain axis because it largely contributes to both GI and brain physiology. In addition, intestinal microbiota are crucial in serotonin signaling, which gives more relevance to the role of the serotonin as an important mediator in microbiota–host interactions. Despite the numerous investigations focused on the gut–brain axis and the pathologies associated, little is known regarding how serotonin can mediate in the microbiota–gut–brain axis. In this review, we will mainly discuss serotonergic system modulation by microbiota as a pathway of communication between intestinal microbes and the body on the microbiota–gut–brain axis, and we explore novel therapeutic approaches for GI diseases and mental disorders.
format	article
author	Elena Layunta Elena Layunta Berta Buey Jose Emilio Mesonero Jose Emilio Mesonero Jose Emilio Mesonero Eva Latorre Eva Latorre Eva Latorre
author_facet	Elena Layunta Elena Layunta Berta Buey Jose Emilio Mesonero Jose Emilio Mesonero Jose Emilio Mesonero Eva Latorre Eva Latorre Eva Latorre
author_sort	Elena Layunta
title	Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis
title_short	Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis
title_full	Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis
title_fullStr	Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis
title_full_unstemmed	Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis
title_sort	crosstalk between intestinal serotonergic system and pattern recognition receptors on the microbiota–gut–brain axis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/afa7a2f4f69f4d958a373502d21ec847
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Crosstalk Between Intestinal Serotonergic System and Pattern Recognition Receptors on the Microbiota–Gut–Brain Axis

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