Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach

Ghanbar Mahmoodi Chalbatani,1,* Hassan Dana,1,2,* Elahe Gharagouzloo,1 Santiago Grijalvo,3,4 Ramon Eritja,3,4 Craig D Logsdon,5,6 Fereidoon Memari,1 Seyed Rouhollah Miri,1 Mahdi Rezvani Rad,7 Vahid Marmari21Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehra...

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Autores principales:	Mahmoodi Chalbatani G, Dana H, Gharagouzloo E, Grijalvo S, Eritja R, Logsdon CD, Memari F, Miri SR, Rad MR, Marmari V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	siRNA Delivery strategies Polymeric Nanoparticles Nanovectors Lipoplexes Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/afaa8579a0304db3bbacefbefa324409
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spelling	oai:doaj.org-article:afaa8579a0304db3bbacefbefa3244092021-12-02T03:15:59ZSmall interfering RNAs (siRNAs) in cancer therapy: a nano-based approach1178-2013https://doaj.org/article/afaa8579a0304db3bbacefbefa3244092019-05-01T00:00:00Zhttps://www.dovepress.com/small-interfering-rnas-sirnas-in-cancer-therapy-a-nano-based-approach-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ghanbar Mahmoodi Chalbatani,1,* Hassan Dana,1,2,* Elahe Gharagouzloo,1 Santiago Grijalvo,3,4 Ramon Eritja,3,4 Craig D Logsdon,5,6 Fereidoon Memari,1 Seyed Rouhollah Miri,1 Mahdi Rezvani Rad,7 Vahid Marmari21Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran; 2Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran; 3Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona 08034, Spain; 4Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER BBN), Madrid, Spain; 5Department of Cancer Biology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA; 6Department of GI Medical Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA; 7Department of Biology, Zabol University, Zabol, Iran*These authors contributed equally to this workAbstract: Cancer is one of the most complex diseases that has resulted in multiple genetic disorders and cellular abnormalities. Globally, cancer is the most common health concern disease that is affecting human beings. Great efforts have been made over the past decades in biology with the aim of searching novel and more efficient tools in therapy. Thus, small interfering RNAs (siRNAs) have been considered one of the most noteworthy developments which are able to regulate gene expression following a process known as RNA interference (RNAi). RNAi is a post-transcriptional mechanism that involves the inhibition of gene expression through promoting cleavage on a specific area of a target messenger RNA (mRNA). This technology has shown promising therapeutic results for a good number of diseases, especially in cancer. However, siRNA therapeutics have to face important drawbacks in therapy including stability and successful siRNA delivery in vivo. In this regard, the development of effective siRNA delivery systems has helped addressing these issues by opening novel therapeutic windows which have allowed to build up important advances in Nanomedicine. In this review, we discuss the progress of siRNA therapy as well as its medical application via nanoparticle-mediated delivery for cancer treatment.Keywords: delivery strategies, lipoplexes, nanovectors, polymeric nanoparticles, siRNAMahmoodi Chalbatani GDana HGharagouzloo EGrijalvo SEritja RLogsdon CDMemari FMiri SRRad MRMarmari VDove Medical PressarticlesiRNADelivery strategiesPolymeric NanoparticlesNanovectorsLipoplexesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 3111-3128 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	siRNA Delivery strategies Polymeric Nanoparticles Nanovectors Lipoplexes Medicine (General) R5-920
spellingShingle	siRNA Delivery strategies Polymeric Nanoparticles Nanovectors Lipoplexes Medicine (General) R5-920 Mahmoodi Chalbatani G Dana H Gharagouzloo E Grijalvo S Eritja R Logsdon CD Memari F Miri SR Rad MR Marmari V Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach
description	Ghanbar Mahmoodi Chalbatani,1,* Hassan Dana,1,2,* Elahe Gharagouzloo,1 Santiago Grijalvo,3,4 Ramon Eritja,3,4 Craig D Logsdon,5,6 Fereidoon Memari,1 Seyed Rouhollah Miri,1 Mahdi Rezvani Rad,7 Vahid Marmari21Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran; 2Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran; 3Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona 08034, Spain; 4Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER BBN), Madrid, Spain; 5Department of Cancer Biology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA; 6Department of GI Medical Oncology, University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA; 7Department of Biology, Zabol University, Zabol, Iran*These authors contributed equally to this workAbstract: Cancer is one of the most complex diseases that has resulted in multiple genetic disorders and cellular abnormalities. Globally, cancer is the most common health concern disease that is affecting human beings. Great efforts have been made over the past decades in biology with the aim of searching novel and more efficient tools in therapy. Thus, small interfering RNAs (siRNAs) have been considered one of the most noteworthy developments which are able to regulate gene expression following a process known as RNA interference (RNAi). RNAi is a post-transcriptional mechanism that involves the inhibition of gene expression through promoting cleavage on a specific area of a target messenger RNA (mRNA). This technology has shown promising therapeutic results for a good number of diseases, especially in cancer. However, siRNA therapeutics have to face important drawbacks in therapy including stability and successful siRNA delivery in vivo. In this regard, the development of effective siRNA delivery systems has helped addressing these issues by opening novel therapeutic windows which have allowed to build up important advances in Nanomedicine. In this review, we discuss the progress of siRNA therapy as well as its medical application via nanoparticle-mediated delivery for cancer treatment.Keywords: delivery strategies, lipoplexes, nanovectors, polymeric nanoparticles, siRNA
format	article
author	Mahmoodi Chalbatani G Dana H Gharagouzloo E Grijalvo S Eritja R Logsdon CD Memari F Miri SR Rad MR Marmari V
author_facet	Mahmoodi Chalbatani G Dana H Gharagouzloo E Grijalvo S Eritja R Logsdon CD Memari F Miri SR Rad MR Marmari V
author_sort	Mahmoodi Chalbatani G
title	Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach
title_short	Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach
title_full	Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach
title_fullStr	Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach
title_full_unstemmed	Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach
title_sort	small interfering rnas (sirnas) in cancer therapy: a nano-based approach
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/afaa8579a0304db3bbacefbefa324409
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Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach

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